Inclisiran

Inclisiran is an injected medicine that lowers LDL cholesterol by switching off the instructions that make the PCSK9 protein. A health professional gives it. A large outcome trial, ORION-4, has not yet reported whether it reduces heart events.

Also called Leqvio

Drug
In this atlas

Overview

Technical summary

RxNorm ingredient 2588243. A double-stranded small interfering RNA (siRNA) that directs breakdown of the messenger RNA for PCSK9, per the FDA label. Brand product: Leqvio. Outcomes evidence is pending: the ORION-4 registry record is active, not recruiting.

About this drug

Level: Substance
Mechanism: siRNA that directs catalytic breakdown of the mRNA for PCSK9, which increases LDL receptor recycling and lowers LDL-C (FDA label)

Claims and evidence

No claims are published for this drug yet.

Record details

Record id: cardio:inclisiran
Content hash: 75485cbe8a17952ecd23cdee68b256501c2916c267e8f587443d49924fc24a9a