Drugs
20 records in the Explore section, by name.
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Alirocumab is an antibody, given by injection, that blocks the PCSK9 protein and lowers LDL cholesterol. In ODYSSEY OUTCOMES it lowered the rate of further heart and blood-vessel events in people...
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The medicine inside Eliquis. It is a blood thinner taken by mouth. In the ARISTOTLE trial it was compared with warfarin in people with atrial fibrillation at higher risk of stroke, and the authors...
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The medicine aspirin, also called acetylsalicylic acid.
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Bempedoic acid is a daily pill that lowers LDL cholesterol. In CLEAR Outcomes, which enrolled people who could not take statins, it lowered a combined set of heart events in statin-intolerant people...
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Colchicine is an old medicine, best known for gout, that has anti-inflammatory effects. In the LoDoCo2 trial, a low daily dose lowered the rate of heart and blood-vessel events in people with chronic...
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The medicine inside Pradaxa. It is a blood thinner taken by mouth. In the RE-LY trial two doses were compared with warfarin in people with atrial fibrillation at risk of stroke. The higher dose gave...
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The medicine inside Farxiga. It is an SGLT2 inhibitor. DAPA-HF tested it in adults with heart failure and an ejection fraction of 40% or less, and DELIVER tested it above 40%. In both trials fewer...
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The medicine inside Jardiance. It is an SGLT2 inhibitor. EMPEROR-Reduced tested it in adults with heart failure and an ejection fraction of 40% or less, and EMPEROR-Preserved tested it above 40%. In...
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Evolocumab is an antibody, given by injection, that blocks the PCSK9 protein and lowers LDL cholesterol by about 60% in the FOURIER abstract. In FOURIER it reduced heart and blood-vessel events in...
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Ezetimibe is a cholesterol pill that is not a statin. It works by reducing how much cholesterol the gut absorbs. In IMPROVE-IT, adding it to a statin after an acute coronary syndrome lowered LDL...
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The medicine inside Kerendia. It is a pill that blocks the mineralocorticoid receptor and is not a steroid. In the FIDELIO-DKD trial it lowered the risk of kidney disease getting worse in people with...
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A group of diabetes medicines called GLP-1 receptor agonists. Some are given as a weekly injection. Large trials in people with type 2 diabetes asked whether they lower the chance of heart attack...
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Inclisiran is an injected medicine that lowers LDL cholesterol by switching off the instructions that make the PCSK9 protein. A health professional gives it. A large outcome trial, ORION-4, has not...
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A class of medicines that includes the aldosterone antagonists, such as spironolactone. NHLBI groups aldosterone antagonists with diuretics as medicines that clear excess salt and water from the...
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The medicine inside Xarelto. It is a blood thinner taken by mouth. In the ROCKET AF trial it was compared with warfarin in people with non-valvular atrial fibrillation at increased risk of stroke. It...
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A two-ingredient pill, sold as Entresto. PARADIGM-HF tested it, under the name LCZ696, against enalapril in adults with heart failure and an ejection fraction of 40% or less. The trial was stopped...
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The medicine inside Ozempic and Wegovy. It is a GLP-1 receptor agonist given as an injection once a week. The SELECT trial tested semaglutide 2.4 mg in adults with heart disease and overweight or...
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A group of pills that NHLBI says were approved for diabetes because they lower blood sugar. Four trials in this atlas tested dapagliflozin or empagliflozin in adults with heart failure. In each, the...
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Statins are the most common medicines used to treat high cholesterol. They lower LDL cholesterol by slowing down how much cholesterol the liver makes. Most of the other cholesterol medicines in this...
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The medicine inside Mounjaro. It is given as an injection once a week and acts on two receptors, called GIP and GLP-1. The SURPASS-CVOT trial compared it with dulaglutide in adults with type 2...