PCSK9 (gene and protein)
PCSK9 is a gene, and the protein it makes, that helps control how much cholesterol stays in the blood. The PCSK9 protein breaks down the receptors that pull LDL out of the blood, so blocking it lets the liver clear more LDL. The PCSK9 antibodies and inclisiran in this atlas work on it.
Also called PCSK9 · Proprotein convertase subtilisin/kexin type 9
- Biological target
- In this atlas
Overview
Technical summary
MedlinePlus Genetics describes the PCSK9 gene and its protein. The antibodies evolocumab and alirocumab bind the protein, and inclisiran breaks down the messenger RNA for PCSK9, as the FDA labels say, so the target here covers the gene, its RNA and its protein.
Target
- Type
- Protein
- Identity
- The PCSK9 gene (proprotein convertase subtilisin/kexin type 9) and the protein it encodes, which breaks down LDL receptors on liver cells
Claims and evidence
No claims are published for this biological target yet.
Record details
- Record id
cardio:pcsk9- Content hash
bad7cd1a90f989110a7815940240cc235a41edf300a85a7695b84cd2503cb4b7