{
  "release_id": "f6f6f1b6f50379ed",
  "id": "cardio:pcsk9",
  "owner": "cardio",
  "kind": "biological_target",
  "slug": "pcsk9",
  "name": "PCSK9 (gene and protein)",
  "aliases": [
    "PCSK9",
    "Proprotein convertase subtilisin/kexin type 9"
  ],
  "atlases": [
    "cardio"
  ],
  "summary_plain": "PCSK9 is a gene, and the protein it makes, that helps control how much cholesterol stays in the blood. The PCSK9 protein breaks down the receptors that pull LDL out of the blood, so blocking it lets the liver clear more LDL. The PCSK9 antibodies and inclisiran in this atlas work on it.",
  "summary_technical": "MedlinePlus Genetics describes the PCSK9 gene and its protein. The antibodies evolocumab and alirocumab bind the protein, and inclisiran breaks down the messenger RNA for PCSK9, as the US drug labels say, so the target here covers the gene, its RNA and its protein.",
  "editorial_state": "draft",
  "last_substantive_edit": "2026-10-15",
  "last_evidence_check": "2026-10-14",
  "next_review_due": null,
  "identifiers": [],
  "navigation": {
    "cardio": {
      "system": [
        "metabolism"
      ],
      "condition-area": [
        "coronary-and-vascular-disease"
      ]
    }
  },
  "payload": {
    "target_type": "protein",
    "identity": "The PCSK9 gene (proprotein convertase subtilisin/kexin type 9) and the protein it encodes, which breaks down LDL receptors on liver cells"
  },
  "content_digest": "ff18d361adc03f1cc161bae9188d504ac23bb4629379b3f4c37d49cf437a654e",
  "review": {
    "content_digest": "ff18d361adc03f1cc161bae9188d504ac23bb4629379b3f4c37d49cf437a654e",
    "current": [],
    "conflicting": [],
    "stale": [],
    "inactive": []
  },
  "claims": [],
  "decisions": [],
  "milestones": [],
  "relationships": {
    "outgoing": [
      {
        "predicate": "related_to",
        "label": "Controls how much LDL cholesterol stays in the blood",
        "clinical_claim_not_fact": false,
        "family": "navigation",
        "other_entity_id": "cardio:high-ldl-cholesterol",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": null,
        "primary": false,
        "role": null,
        "valid_from": null,
        "valid_to": null
      }
    ],
    "incoming": [
      {
        "predicate": "related_to",
        "label": "Related to",
        "clinical_claim_not_fact": false,
        "family": "navigation",
        "other_entity_id": "core:medlineplus",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": null,
        "primary": false,
        "role": null,
        "valid_from": null,
        "valid_to": null
      },
      {
        "predicate": "targets",
        "label": "Targeted by",
        "clinical_claim_not_fact": false,
        "family": "sourced",
        "other_entity_id": "cardio:alirocumab",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": {
          "snapshot_id": "cardio:openfda-label-446f6b5c-0dd4-44ff-9bc2-c2b41f2806b4-2026-10-14",
          "locator": "results[0].mechanism_of_action[0]"
        },
        "primary": false,
        "role": null,
        "valid_from": null,
        "valid_to": null
      },
      {
        "predicate": "targets",
        "label": "Targeted by",
        "clinical_claim_not_fact": false,
        "family": "sourced",
        "other_entity_id": "cardio:evolocumab",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": {
          "snapshot_id": "cardio:openfda-label-cd61e902-166d-4aa6-9f3c-a18c1008d07e-2026-10-14",
          "locator": "results[0].mechanism_of_action[0]"
        },
        "primary": false,
        "role": null,
        "valid_from": null,
        "valid_to": null
      },
      {
        "predicate": "targets",
        "label": "Targeted by",
        "clinical_claim_not_fact": false,
        "family": "sourced",
        "other_entity_id": "cardio:inclisiran",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": {
          "snapshot_id": "cardio:openfda-label-6fc0afca-4513-4c35-b594-6544aee29a44-2026-10-14",
          "locator": "results[0].mechanism_of_action[0]"
        },
        "primary": false,
        "role": null,
        "valid_from": null,
        "valid_to": null
      }
    ]
  },
  "page_path": "biological-targets/pcsk9/",
  "context_path": "api/v1/context/cardio--pcsk9.md"
}