{
  "release_id": "f6f6f1b6f50379ed",
  "id": "cardio:inclisiran",
  "owner": "cardio",
  "kind": "drug",
  "slug": "inclisiran",
  "name": "Inclisiran",
  "aliases": [
    "Leqvio"
  ],
  "atlases": [
    "cardio"
  ],
  "summary_plain": "Inclisiran is an injected medicine that lowers LDL cholesterol by switching off the instructions that make the PCSK9 protein. A health professional gives it. A large outcome trial, ORION-4, has not yet reported whether it reduces heart events.",
  "summary_technical": "RxNorm ingredient 2588243. A double-stranded small interfering RNA (siRNA) that directs breakdown of the messenger RNA for PCSK9, per the US drug label. Brand product: Leqvio. Outcomes evidence is pending: the ORION-4 registry record is active, not recruiting.",
  "editorial_state": "draft",
  "last_substantive_edit": "2026-10-15",
  "last_evidence_check": "2026-10-14",
  "next_review_due": null,
  "identifiers": [
    {
      "scheme": "rxnorm",
      "value": "2588243",
      "normalized_value": "2588243",
      "match": "exact",
      "version": null,
      "label": null,
      "from_source": false
    }
  ],
  "navigation": {
    "cardio": {
      "condition-area": [
        "coronary-and-vascular-disease"
      ]
    }
  },
  "payload": {
    "level": "substance",
    "mechanism": "siRNA that directs catalytic breakdown of the mRNA for PCSK9, which increases LDL receptor recycling and lowers LDL-C (US drug label)"
  },
  "content_digest": "0f33685eb93d967782cf16dcbd4046dea4579a2c486fad77339ef977335d00de",
  "review": {
    "content_digest": "0f33685eb93d967782cf16dcbd4046dea4579a2c486fad77339ef977335d00de",
    "current": [],
    "conflicting": [],
    "stale": [],
    "inactive": []
  },
  "claims": [],
  "decisions": [],
  "milestones": [],
  "relationships": {
    "outgoing": [
      {
        "predicate": "targets",
        "label": "Breaks down the messenger RNA that codes for PCSK9",
        "clinical_claim_not_fact": false,
        "family": "sourced",
        "other_entity_id": "cardio:pcsk9",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": {
          "snapshot_id": "cardio:openfda-label-6fc0afca-4513-4c35-b594-6544aee29a44-2026-10-14",
          "locator": "results[0].mechanism_of_action[0]"
        },
        "primary": false,
        "role": null,
        "valid_from": null,
        "valid_to": null
      },
      {
        "predicate": "part_of",
        "label": "Files under this front",
        "clinical_claim_not_fact": false,
        "family": "navigation",
        "other_entity_id": "cardio:front-medicines",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": null,
        "primary": true,
        "role": null,
        "valid_from": null,
        "valid_to": null
      }
    ],
    "incoming": [
      {
        "predicate": "contains",
        "label": "Contained in",
        "clinical_claim_not_fact": false,
        "family": "sourced",
        "other_entity_id": "cardio:leqvio",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": {
          "snapshot_id": "cardio:openfda-drugsfda-nda214012-2026-10-14",
          "locator": "results[0].products[0].active_ingredients[0].name"
        },
        "primary": false,
        "role": null,
        "valid_from": null,
        "valid_to": null
      },
      {
        "predicate": "investigates",
        "label": "Investigated in",
        "clinical_claim_not_fact": false,
        "family": "sourced",
        "other_entity_id": "cardio:orion-4",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": {
          "snapshot_id": "cardio:ctgov-nct03705234-2026-10-14",
          "locator": "protocolSection.armsInterventionsModule.interventions[0].name"
        },
        "primary": false,
        "role": null,
        "valid_from": null,
        "valid_to": null
      }
    ]
  },
  "page_path": "drugs/inclisiran/",
  "context_path": "api/v1/context/cardio--inclisiran.md"
}