SPRINT primary composite cardiovascular outcome

A combined count of heart attacks, other sudden heart-artery problems, strokes, heart failure and deaths from heart or blood-vessel causes.

Outcome
In this atlas

Overview

Technical summary

First occurrence of any component. Adjudicated by assessors who did not know the assignment. The abstract and the registry use shorter wording than the paper's Methods.

Definition

First occurrence of myocardial infarction, acute coronary syndrome not resulting in myocardial infarction, stroke, acute decompensated heart failure, or death from cardiovascular causes (paper, Methods)

Unit: patients
Components: Myocardial infarction (SPRINT component)
Acute coronary syndrome not resulting in myocardial infarction (SPRINT component)
Stroke as an outcome
Acute decompensated heart failure (SPRINT component)
Death from cardiovascular causes (SPRINT component)

Measured in

Studies in this atlas that report this outcome, by the claim each finding supports. Each finding keeps its own population, denominator and time window on the study page.

Primary endpoint Systolic Blood Pressure Intervention Trial (SPRINT) See the findings
Applies to Adult
- Adults aged 50 years or older with systolic blood pressure of 130 to 180 mm Hg (the registry lowers the upper limit as the number of blood-pressure medicines rises) and at least one increased-risk criterion, excluding diabetes mellitus and prior stroke.
- Outpatient trial clinics at 102 clinical sites. Nursing-home and assisted-living residents were not enrolled.
- United States, including Puerto Rico
- Adult, 50 years and over (28.2% of each arm aged 75 or over, per Table 1 of the paper)
Follow-up Median follow-up 3.26 years when the blood-pressure intervention was stopped early on 2015-08-20. The registry gives a planned maximum follow-up of 6 years. Mean systolic pressure at 1 year was 121.4 mm Hg (intensive) and 136.2 mm Hg (standard).
In SPRINT, adults aged 50 and over at raised heart risk, without diabetes or a past stroke, whose treatment aimed for a top (systolic) blood pressure below 120 mm Hg had fewer major heart and blood-vessel events than those aiming for below 140. Over a median of 3.26 years, 243 of 4678 people in the lower-target group and 319 of 4683 in the standard group had a first primary-outcome event (hazard ratio 0.75, 95% CI 0.64 to 0.89).
Source problem. A cited source is corrected. Check the sources before relying on this claim.
Limitations. One open-label trial; outcome adjudicators did not know the assignment. The blood-pressure intervention was stopped early for benefit after crossing a monitoring boundary. The authors say the results do not generalize to people with diabetes, prior stroke or age under 50, or to nursing-home residents. The paper and the registry word the older-age entry criterion differently ("75 years or older" versus "greater than 75 years"), and this is not reconciled. The publication has a 2017 erratum whose content was not verified. Full-text figures come from the PMC author manuscript.

Record details

Record id: cardio:outcome-sprint-primary-composite
Content hash: 64cb81c8c56fa3f292409a6e3fafcab3c0d2f5bcd399d55c3c68d5be9bcd83d7