{
  "release_id": "f6f6f1b6f50379ed",
  "id": "cardio:uacr",
  "owner": "cardio",
  "kind": "biomarker",
  "slug": "uacr",
  "name": "Urine albumin-to-creatinine ratio (UACR)",
  "aliases": [
    "UACR",
    "Microalbumin creatinine ratio",
    "Albumin-creatinine ratio",
    "ACR"
  ],
  "atlases": [
    "cardio"
  ],
  "summary_plain": "A urine test that compares the amount of the protein albumin with creatinine. Healthy kidneys let only a trace of albumin into the urine, so more than that can be an early sign of kidney damage.",
  "summary_technical": "Used with eGFR to find and follow chronic kidney disease. A urinary albumin-to-creatinine ratio threshold is part of the entry criteria of four kidney-outcome trials in this atlas; the thresholds differ by trial and are given on each trial record.",
  "editorial_state": "draft",
  "last_substantive_edit": "2026-10-15",
  "last_evidence_check": null,
  "next_review_due": null,
  "identifiers": [
    {
      "scheme": "mesh",
      "value": "D000419",
      "normalized_value": "D000419",
      "match": "broad",
      "version": "2026",
      "label": null,
      "from_source": false
    }
  ],
  "navigation": {
    "cardio": {
      "system": [
        "kidneys"
      ],
      "condition-area": [
        "kidney-connections"
      ]
    }
  },
  "payload": {
    "measure": "The ratio of the protein albumin to creatinine in a urine sample.",
    "assay_context": "A single urine sample or a timed sample; the page read describes random, early-morning and 24-hour collection.",
    "interpretation_claims": [
      "cardio:claim-uacr-use"
    ]
  },
  "content_digest": "1557cd77946bfec0845643c9c08d85381651e95ac4097105d46deb0f2689dab6",
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  "claims": [
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      "release_id": "f6f6f1b6f50379ed",
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      "subject_entity_id": "cardio:uacr",
      "category": "descriptive",
      "statement": "MedlinePlus says a microalbumin creatinine ratio urine test checks the level of the protein albumin in the urine, and that abnormal amounts may be an early sign of kidney disease. It is most often used to look for signs of kidney disease in people who have a high risk of developing it but no symptoms, for example people with diabetes or high blood pressure. It may also be used to monitor the kidneys of people who have been diagnosed with kidney disease. The page says that anyone with diabetes should be tested for kidney disease every year.",
      "context": {
        "id": "cardio:ctx-adults-with-or-at-risk-of-ckd-nih-pages",
        "label": "Adults with chronic kidney disease or at risk of it (NIDDK and MedlinePlus patient pages)",
        "recipient": "adult",
        "population": "Adults with chronic kidney disease, or at higher risk of it, for example because of diabetes or high blood pressure.",
        "care_setting": "Not stated; patient information pages",
        "geography": "Not stated; United States federal health agencies",
        "life_stage_note": "Adults",
        "life_stage_terms": null,
        "gestational_age_min_days": null,
        "gestational_age_max_days": null,
        "gestational_age_basis": null,
        "postnatal_age_min_days": null,
        "postnatal_age_max_days": null,
        "gestational_age_status": null,
        "postnatal_age_status": null,
        "followup_description": "Not applicable (descriptive page)",
        "eligibility": {
          "inclusion": [],
          "exclusion": []
        }
      },
      "evidence_stage": "not_applicable",
      "certainty": "not_assessed",
      "certainty_method": null,
      "limitations": "A patient-information page from the National Library of Medicine. The passages read give no ratio thresholds, so this atlas gives none. The threshold used for entry differs between trials and is given on each trial record.",
      "editorial_state": "draft",
      "checked_at": "2026-10-14",
      "next_review_due": null,
      "valid_from": null,
      "valid_to": null,
      "citations": [
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          "evidence_role": "supports",
          "locator": "What is a microalbumin creatinine ratio test?, para 1",
          "applicability_note": "What the test measures and what abnormal amounts may mean.",
          "snapshot": {
            "id": "cardio:medlineplus-uacr-test-2026-10-14",
            "retrieved_at": "2026-10-14T18:30:06Z",
            "content_hash": "8d0469477df4f4a7b48be545bfeaaf678f1d4efd064e52babb40c5ba521c000d",
            "source_effective_date": null,
            "public_archive_url": null,
            "source_state": "current"
          },
          "source": {
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            "source_type": "webpage",
            "title": "MedlinePlus medical test: Microalbumin Creatinine Ratio",
            "canonical_url": "https://medlineplus.gov/lab-tests/microalbumin-creatinine-ratio/",
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            "publication_date": null,
            "publisher": "U.S. National Library of Medicine (MedlinePlus)",
            "edition": "MedlinePlus page fetched 2026-10-14; the page footer says last updated May 27, 2025.",
            "reuse_basis": "The MedlinePlus page on using its content (fetched 2026-10-14 as ch-medlineplus-usingcontent.html, sha256 31267ce9db01, hash only) says works produced by the federal government are not copyrighted, and lists summaries on health topic pages and medical test information as public domain; A.D.A.M. Medical Encyclopedia articles are copyrighted, and this atlas cites none. Please acknowledge MedlinePlus, National Library of Medicine, as the source. The raw page is committed at research/snapshots/ch-medlineplus-uacr-test.html.",
            "public_text": "quote"
          }
        },
        {
          "evidence_role": "supports",
          "locator": "What is it used for?, para 1; What is it used for?, list; What is it used for?, para 3",
          "applicability_note": "Who is tested and for what.",
          "snapshot": {
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          },
          "source": {
            "id": "cardio:medlineplus-uacr-test",
            "source_type": "webpage",
            "title": "MedlinePlus medical test: Microalbumin Creatinine Ratio",
            "canonical_url": "https://medlineplus.gov/lab-tests/microalbumin-creatinine-ratio/",
            "identifiers": [],
            "publication_date": null,
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            "reuse_basis": "The MedlinePlus page on using its content (fetched 2026-10-14 as ch-medlineplus-usingcontent.html, sha256 31267ce9db01, hash only) says works produced by the federal government are not copyrighted, and lists summaries on health topic pages and medical test information as public domain; A.D.A.M. Medical Encyclopedia articles are copyrighted, and this atlas cites none. Please acknowledge MedlinePlus, National Library of Medicine, as the source. The raw page is committed at research/snapshots/ch-medlineplus-uacr-test.html.",
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          }
        },
        {
          "evidence_role": "supports",
          "locator": "Why do I need a microalbumin creatinine ratio test?, para 2",
          "applicability_note": "Yearly testing for people with diabetes.",
          "snapshot": {
            "id": "cardio:medlineplus-uacr-test-2026-10-14",
            "retrieved_at": "2026-10-14T18:30:06Z",
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          },
          "source": {
            "id": "cardio:medlineplus-uacr-test",
            "source_type": "webpage",
            "title": "MedlinePlus medical test: Microalbumin Creatinine Ratio",
            "canonical_url": "https://medlineplus.gov/lab-tests/microalbumin-creatinine-ratio/",
            "identifiers": [],
            "publication_date": null,
            "publisher": "U.S. National Library of Medicine (MedlinePlus)",
            "edition": "MedlinePlus page fetched 2026-10-14; the page footer says last updated May 27, 2025.",
            "reuse_basis": "The MedlinePlus page on using its content (fetched 2026-10-14 as ch-medlineplus-usingcontent.html, sha256 31267ce9db01, hash only) says works produced by the federal government are not copyrighted, and lists summaries on health topic pages and medical test information as public domain; A.D.A.M. Medical Encyclopedia articles are copyrighted, and this atlas cites none. Please acknowledge MedlinePlus, National Library of Medicine, as the source. The raw page is committed at research/snapshots/ch-medlineplus-uacr-test.html.",
            "public_text": "quote"
          }
        }
      ],
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      "api_path": "api/v1/claims/cardio--claim-uacr-use.json"
    }
  ],
  "decisions": [],
  "milestones": [],
  "relationships": {
    "outgoing": [
      {
        "predicate": "evaluated_for",
        "label": "Used to look for early signs of kidney disease",
        "clinical_claim_not_fact": true,
        "family": "clinical",
        "other_entity_id": "cardio:chronic-kidney-disease",
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  "page_path": "biomarkers/uacr/",
  "context_path": "api/v1/context/cardio--uacr.md"
}