{
  "release_id": "73130c34862e2d06",
  "id": "cardio:ttm2",
  "owner": "cardio",
  "kind": "study",
  "slug": "ttm2",
  "name": "TTM2",
  "aliases": [
    "TTM-2",
    "Targeted Hypothermia Versus Targeted Normothermia After Out-of-hospital Cardiac Arrest"
  ],
  "atlases": [
    "cardio"
  ],
  "summary_plain": "A randomized trial in 1900 adults who were in a coma after a cardiac arrest outside hospital, of presumed cardiac or unknown cause. One group was cooled to 33 degrees C and then rewarmed in a controlled way; the other was kept at a normal temperature, with the fever treated early. After 6 months, deaths were about the same: 50% with cooling and 48% with normothermia. Heart rhythm problems that affected circulation were more common with cooling (24% against 17%).",
  "summary_technical": "ClinicalTrials.gov NCT02908308: a randomized, parallel-group study, phase not applicable, with Helsingborgs Hospital as lead sponsor (no organization record is kept for it here), status completed, start 2017-11-18, primary completion 2022-06-30 and completion 2022-12-31 (all actual), enrollment 1900 (actual) and locations in 14 countries. The registry lists Luxembourg and the Netherlands under removed countries and they are not counted. It lists masking as triple, while its description says the care team was not blinded; the paper's abstract says open-label with blinded outcome assessment. The primary outcome in the registry is mortality over 180 days; the paper's is death from any cause at 6 months. The record holds no results. The numbers are on the claim.",
  "editorial_state": "draft",
  "last_substantive_edit": "2026-10-15",
  "last_evidence_check": "2026-10-15",
  "next_review_due": null,
  "identifiers": [
    {
      "scheme": "nct",
      "value": "NCT02908308",
      "normalized_value": "NCT02908308",
      "match": "exact",
      "version": null,
      "label": null,
      "from_source": false
    }
  ],
  "navigation": {
    "cardio": {
      "condition-area": [
        "acute-care-and-long-term-living"
      ]
    }
  },
  "payload": {
    "design": "Randomized, parallel-group trial. Open-label with blinded assessment of outcomes (abstract); the registry lists masking as triple and its description says the clinical team was not blinded to allocation.",
    "drug_phase": "not_applicable",
    "registry_statuses": [
      {
        "status": "COMPLETED",
        "snapshot": "cardio:ctgov-nct02908308-2026-10-15"
      }
    ],
    "start_date": {
      "date": "2017-11-18",
      "type": "actual",
      "snapshot": "cardio:ctgov-nct02908308-2026-10-15"
    },
    "primary_completion_date": {
      "date": "2022-06-30",
      "type": "actual",
      "snapshot": "cardio:ctgov-nct02908308-2026-10-15"
    },
    "completion_date": {
      "date": "2022-12-31",
      "type": "actual",
      "snapshot": "cardio:ctgov-nct02908308-2026-10-15"
    },
    "results_first_posted": null,
    "countries": [
      {
        "code": "US",
        "snapshot": "cardio:ctgov-nct02908308-2026-10-15"
      },
      {
        "code": "AU",
        "snapshot": "cardio:ctgov-nct02908308-2026-10-15"
      },
      {
        "code": "AT",
        "snapshot": "cardio:ctgov-nct02908308-2026-10-15"
      },
      {
        "code": "BE",
        "snapshot": "cardio:ctgov-nct02908308-2026-10-15"
      },
      {
        "code": "CZ",
        "snapshot": "cardio:ctgov-nct02908308-2026-10-15"
      },
      {
        "code": "DK",
        "snapshot": "cardio:ctgov-nct02908308-2026-10-15"
      },
      {
        "code": "FR",
        "snapshot": "cardio:ctgov-nct02908308-2026-10-15"
      },
      {
        "code": "DE",
        "snapshot": "cardio:ctgov-nct02908308-2026-10-15"
      },
      {
        "code": "IT",
        "snapshot": "cardio:ctgov-nct02908308-2026-10-15"
      },
      {
        "code": "NZ",
        "snapshot": "cardio:ctgov-nct02908308-2026-10-15"
      },
      {
        "code": "NO",
        "snapshot": "cardio:ctgov-nct02908308-2026-10-15"
      },
      {
        "code": "SE",
        "snapshot": "cardio:ctgov-nct02908308-2026-10-15"
      },
      {
        "code": "CH",
        "snapshot": "cardio:ctgov-nct02908308-2026-10-15"
      },
      {
        "code": "GB",
        "snapshot": "cardio:ctgov-nct02908308-2026-10-15"
      }
    ],
    "care_setting": null,
    "stopped_early": null,
    "enrollment": [
      {
        "count": 1900,
        "basis": "enrolled",
        "unit": "participants",
        "snapshot": "cardio:ctgov-nct02908308-2026-10-15"
      }
    ],
    "arms": [
      {
        "id": "cardio:ttm2-arm-hypothermia",
        "label": "Targeted hypothermia",
        "intervention": "cardio:temperature-control-after-arrest",
        "description": "Targeted temperature management to 33 degrees C followed by controlled rewarming (abstract); the registry says up to 28 hours. 925 patients were evaluated for the primary outcome."
      },
      {
        "id": "cardio:ttm2-arm-normothermia",
        "label": "Targeted normothermia with early treatment of fever",
        "intervention": "cardio:temperature-control-after-arrest",
        "description": "Standard care with early treatment of fever; the registry says active temperature control with a device is used if the patient's temperature reaches 37.8 degrees C or higher. 925 patients were evaluated for the primary outcome."
      }
    ],
    "findings": []
  },
  "content_digest": "3cbda113eb68f0d13f5ae8b8eebbf0aa11d3bf44c75e7aa923094d6d2e8daa7c",
  "review": {
    "content_digest": "3cbda113eb68f0d13f5ae8b8eebbf0aa11d3bf44c75e7aa923094d6d2e8daa7c",
    "current": [],
    "conflicting": [],
    "stale": [],
    "inactive": []
  },
  "claims": [],
  "decisions": [],
  "milestones": [],
  "relationships": {
    "outgoing": [
      {
        "predicate": "investigates",
        "label": "Compares cooling to 33 degrees C with targeted normothermia",
        "clinical_claim_not_fact": false,
        "family": "sourced",
        "other_entity_id": "cardio:temperature-control-after-arrest",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": {
          "snapshot_id": "cardio:ctgov-nct02908308-2026-10-15",
          "locator": "protocolSection.armsInterventionsModule.interventions[0].name"
        },
        "primary": false,
        "role": null,
        "valid_from": null,
        "valid_to": null
      },
      {
        "predicate": "investigates",
        "label": "Lists out-of-hospital cardiac arrest as its condition",
        "clinical_claim_not_fact": false,
        "family": "sourced",
        "other_entity_id": "cardio:sudden-cardiac-arrest",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": {
          "snapshot_id": "cardio:ctgov-nct02908308-2026-10-15",
          "locator": "protocolSection.conditionsModule.conditions[0]"
        },
        "primary": false,
        "role": null,
        "valid_from": null,
        "valid_to": null
      },
      {
        "predicate": "investigates",
        "label": "Primary outcome in the paper (death from any cause at 6 months)",
        "clinical_claim_not_fact": false,
        "family": "sourced",
        "other_entity_id": "core:outcome-death-any-cause",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": {
          "snapshot_id": "cardio:pubmed-34133859-2026-10-15",
          "locator": "Abstract, METHODS, sentence 2"
        },
        "primary": false,
        "role": null,
        "valid_from": null,
        "valid_to": null
      }
    ],
    "incoming": []
  },
  "page_path": "studies/ttm2/",
  "context_path": "api/v1/context/cardio--ttm2.md"
}