{
  "release_id": "f6f6f1b6f50379ed",
  "id": "cardio:surgical-aortic-valve-replacement",
  "owner": "cardio",
  "kind": "intervention",
  "slug": "surgical-aortic-valve-replacement",
  "name": "Surgical aortic valve replacement",
  "aliases": [
    "SAVR",
    "Open-heart aortic valve replacement"
  ],
  "atlases": [
    "cardio"
  ],
  "summary_plain": "An operation in which a surgeon replaces a diseased aortic valve with a mechanical valve or a biological (tissue) valve. It is the comparison for TAVR in the PARTNER 3 and Evolut Low Risk trials. A US government patient page lists stroke and blood clots among the risks of valve replacement, together with injury to the kidneys or heart.",
  "summary_technical": "Open-heart valve replacement, as the comparison for catheter replacement. A US government patient page separates the surgical route from the catheter route and describes mechanical and biological (tissue) valves. In PARTNER 3 the registry describes the comparison as SAVR with a commercially available bioprosthetic valve; the Evolut Low Risk registry says commercial SAVR with a commercially approved surgical bioprosthesis. This record gives no outcome figures of its own: the trial claims are filed under TAVR and the record of the self-expanding valve.",
  "editorial_state": "draft",
  "last_substantive_edit": "2026-10-15",
  "last_evidence_check": "2026-10-14",
  "next_review_due": null,
  "identifiers": [],
  "navigation": {
    "cardio": {
      "system": [
        "heart"
      ],
      "condition-area": [
        "valvular-and-congenital-disease"
      ]
    }
  },
  "payload": {
    "subtype": "procedure",
    "mechanism": "The diseased valve is removed during open-heart surgery and replaced with a mechanical or biological valve (a US government patient page).",
    "components": null
  },
  "content_digest": "bc0e88538309ceca221df1a54130631d1a0fac7723d9b5b35eae2f0dc0e9a726",
  "review": {
    "content_digest": "bc0e88538309ceca221df1a54130631d1a0fac7723d9b5b35eae2f0dc0e9a726",
    "current": [],
    "conflicting": [],
    "stale": [],
    "inactive": []
  },
  "claims": [],
  "decisions": [],
  "milestones": [],
  "relationships": {
    "outgoing": [
      {
        "predicate": "related_to",
        "label": "Comparator",
        "clinical_claim_not_fact": false,
        "family": "navigation",
        "other_entity_id": "cardio:tavr",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": null,
        "primary": false,
        "role": null,
        "valid_from": null,
        "valid_to": null
      },
      {
        "predicate": "part_of",
        "label": "Filed under this front",
        "clinical_claim_not_fact": false,
        "family": "navigation",
        "other_entity_id": "cardio:front-procedures-and-surgery",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": null,
        "primary": true,
        "role": null,
        "valid_from": null,
        "valid_to": null
      }
    ],
    "incoming": [
      {
        "predicate": "investigates",
        "label": "Investigated in",
        "clinical_claim_not_fact": false,
        "family": "sourced",
        "other_entity_id": "cardio:evolut-low-risk",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": {
          "snapshot_id": "cardio:ctgov-nct02701283-2026-10-14",
          "locator": "protocolSection.armsInterventionsModule.interventions[1].name"
        },
        "primary": false,
        "role": null,
        "valid_from": null,
        "valid_to": null
      },
      {
        "predicate": "investigates",
        "label": "Investigated in",
        "clinical_claim_not_fact": false,
        "family": "sourced",
        "other_entity_id": "cardio:partner-3",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": {
          "snapshot_id": "cardio:ctgov-nct02675114-2026-10-14",
          "locator": "protocolSection.armsInterventionsModule.interventions[0].name"
        },
        "primary": false,
        "role": null,
        "valid_from": null,
        "valid_to": null
      }
    ]
  },
  "page_path": "interventions/surgical-aortic-valve-replacement/",
  "context_path": "api/v1/context/cardio--surgical-aortic-valve-replacement.md"
}