{
  "release_id": "5dcd9b263fe17744",
  "id": "cardio:scd-heft",
  "owner": "cardio",
  "kind": "study",
  "slug": "scd-heft",
  "name": "SCD-HeFT",
  "aliases": [
    "Sudden Cardiac Death in Heart Failure Trial"
  ],
  "atlases": [
    "cardio"
  ],
  "summary_plain": "A randomized trial in 2521 people with heart failure (New York Heart Association class II or III, ejection fraction 35% or less). All received usual heart failure care, plus placebo, the drug amiodarone, or an implantable cardioverter-defibrillator (ICD). After a median of 45.5 months, fewer people had died in the ICD group (22%) than in the placebo group (29%). The amiodarone group (28%) had a similar risk of death to the placebo group.",
  "summary_technical": "ClinicalTrials.gov NCT00000609: a phase 3 randomized treatment study with the National Heart, Lung, and Blood Institute as lead sponsor, status completed, start 1997-05 (the registry gives no date type) and completion 2005-04 (actual). The record lists no locations, no enrollment count and no results; the 2521 randomized patients come from the abstract of the 2005 report (read only as a PubMed abstract). PubMed links an erratum published in May 2005 that was not read. The study's amiodarone and ICD results are on the claim; no structured findings are recorded here.",
  "editorial_state": "draft",
  "last_substantive_edit": "2026-10-15",
  "last_evidence_check": "2026-10-15",
  "next_review_due": null,
  "identifiers": [
    {
      "scheme": "nct",
      "value": "NCT00000609",
      "normalized_value": "NCT00000609",
      "match": "exact",
      "version": null,
      "label": null,
      "from_source": false
    }
  ],
  "navigation": {
    "cardio": {
      "condition-area": [
        "arrhythmias"
      ]
    }
  },
  "payload": {
    "design": "Randomized, three-group trial. Conventional therapy plus placebo, conventional therapy plus amiodarone, or conventional therapy plus a conservatively programmed, shock-only, single-lead ICD; placebo and amiodarone were double-blind (abstract). The registry gives allocation randomized and primary purpose treatment.",
    "drug_phase": "3",
    "registry_statuses": [
      {
        "status": "COMPLETED",
        "snapshot": "cardio:ctgov-nct00000609-2026-10-15"
      }
    ],
    "start_date": {
      "date": "1997-05",
      "type": null,
      "snapshot": "cardio:ctgov-nct00000609-2026-10-15"
    },
    "primary_completion_date": null,
    "completion_date": {
      "date": "2005-04",
      "type": "actual",
      "snapshot": "cardio:ctgov-nct00000609-2026-10-15"
    },
    "results_first_posted": null,
    "countries": null,
    "care_setting": null,
    "stopped_early": null,
    "enrollment": [
      {
        "count": 2521,
        "basis": "randomized",
        "unit": "patients",
        "snapshot": "cardio:pubmed-15659722-2026-10-15"
      }
    ],
    "arms": [
      {
        "id": "cardio:scd-heft-arm-placebo",
        "label": "Conventional therapy plus placebo",
        "intervention": null,
        "description": "Conventional therapy for congestive heart failure plus placebo, 847 patients (abstract)."
      },
      {
        "id": "cardio:scd-heft-arm-amiodarone",
        "label": "Conventional therapy plus amiodarone",
        "intervention": null,
        "description": "Conventional therapy for congestive heart failure plus amiodarone, 845 patients (abstract). No separate entity is recorded for amiodarone."
      },
      {
        "id": "cardio:scd-heft-arm-icd",
        "label": "Conventional therapy plus ICD",
        "intervention": "cardio:implantable-cardioverter-defibrillator",
        "description": "Conventional therapy for congestive heart failure plus a conservatively programmed, shock-only, single-lead ICD, 829 patients (abstract)."
      }
    ],
    "findings": []
  },
  "content_digest": "cf9fb895f6b869234eb02d833e59e59437f981797825fe2f9b359a17a5416006",
  "review": {
    "content_digest": "cf9fb895f6b869234eb02d833e59e59437f981797825fe2f9b359a17a5416006",
    "current": [],
    "conflicting": [],
    "stale": [],
    "inactive": []
  },
  "claims": [],
  "decisions": [],
  "milestones": [],
  "relationships": {
    "outgoing": [
      {
        "predicate": "investigates",
        "label": "Tests an ICD against placebo and amiodarone",
        "clinical_claim_not_fact": false,
        "family": "sourced",
        "other_entity_id": "cardio:implantable-cardioverter-defibrillator",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": {
          "snapshot_id": "cardio:ctgov-nct00000609-2026-10-15",
          "locator": "protocolSection.armsInterventionsModule.interventions[1].name"
        },
        "primary": false,
        "role": null,
        "valid_from": null,
        "valid_to": null
      },
      {
        "predicate": "investigates",
        "label": "Lists heart failure as a condition",
        "clinical_claim_not_fact": false,
        "family": "sourced",
        "other_entity_id": "cardio:heart-failure",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": {
          "snapshot_id": "cardio:ctgov-nct00000609-2026-10-15",
          "locator": "protocolSection.conditionsModule.conditions[5]"
        },
        "primary": false,
        "role": null,
        "valid_from": null,
        "valid_to": null
      },
      {
        "predicate": "investigates",
        "label": "Primary end point",
        "clinical_claim_not_fact": false,
        "family": "sourced",
        "other_entity_id": "core:outcome-death-any-cause",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": {
          "snapshot_id": "cardio:pubmed-15659722-2026-10-15",
          "locator": "Abstract, METHODS, sentence 3"
        },
        "primary": false,
        "role": null,
        "valid_from": null,
        "valid_to": null
      },
      {
        "predicate": "sponsored_by",
        "label": "Lead sponsor on the registry record",
        "clinical_claim_not_fact": false,
        "family": "sourced",
        "other_entity_id": "cardio:nhlbi",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": {
          "snapshot_id": "cardio:ctgov-nct00000609-2026-10-15",
          "locator": "protocolSection.sponsorCollaboratorsModule.leadSponsor.name"
        },
        "primary": false,
        "role": "lead",
        "valid_from": null,
        "valid_to": null
      }
    ],
    "incoming": []
  },
  "page_path": "studies/scd-heft/",
  "context_path": "api/v1/context/cardio--scd-heft.md"
}