{
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  "id": "cardio:pub-ischemia-nejm-2020",
  "owner": "cardio",
  "kind": "publication",
  "slug": "pub-ischemia-nejm-2020",
  "name": "ISCHEMIA main results, NEJM 2020",
  "aliases": [
    "Initial Invasive or Conservative Strategy for Stable Coronary Disease"
  ],
  "atlases": [
    "cardio"
  ],
  "summary_plain": "The main results report of the ISCHEMIA trial, published in the New England Journal of Medicine in April 2020. It reports that an initial invasive strategy did not reduce ischemic cardiovascular events or death compared with an initial conservative strategy in people with stable coronary disease and moderate or severe ischemia.",
  "summary_technical": "N Engl J Med, 9 April 2020 (PubMed). DOI 10.1056/NEJMoa1915922; PMID 32227755. PubMed lists a PMC copy (PMC7263833) that is not in the PMC Open Access subset, so only the abstract was read. The author list includes the study chair named on the registry, Judith S Hochman.",
  "editorial_state": "draft",
  "last_substantive_edit": "2026-10-14",
  "last_evidence_check": "2026-10-14",
  "next_review_due": null,
  "identifiers": [
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      "scheme": "doi",
      "value": "10.1056/NEJMoa1915922",
      "normalized_value": "10.1056/nejmoa1915922",
      "match": "exact",
      "version": null,
      "label": null,
      "from_source": true
    },
    {
      "scheme": "pmid",
      "value": "32227755",
      "normalized_value": "32227755",
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      "version": null,
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      "from_source": true
    },
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      "value": "PMC7263833",
      "normalized_value": "PMC7263833",
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      "version": null,
      "label": null,
      "from_source": true
    }
  ],
  "navigation": {
    "cardio": {
      "condition-area": [
        "coronary-and-vascular-disease"
      ]
    }
  },
  "payload": {
    "source": "cardio:pubmed-10-1056-nejmoa1915922",
    "publication_type": "article",
    "plain_interpretation": "The abstract says the authors found no evidence that starting with an invasive strategy reduced the risk of ischemic cardiovascular events or death from any cause over a median of 3.2 years, and that the findings depended on how myocardial infarction was defined."
  },
  "content_digest": "16bec40d2847f7e97940092edafd555353da21a1b073147e7eff40d4b46df369",
  "review": {
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    "current": [],
    "conflicting": [],
    "stale": [],
    "inactive": []
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  "claims": [],
  "decisions": [],
  "milestones": [],
  "relationships": {
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        "predicate": "authored_by",
        "label": "Author; also study chair on the registry record",
        "clinical_claim_not_fact": false,
        "family": "sourced",
        "other_entity_id": "cardio:judith-hochman",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": {
          "snapshot_id": "cardio:pubmed-32227755-2026-10-14",
          "locator": "Author list: Hochman, Judith S (second author)"
        },
        "primary": false,
        "role": null,
        "valid_from": null,
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      },
      {
        "predicate": "published_in",
        "label": "Published in",
        "clinical_claim_not_fact": false,
        "family": "sourced",
        "other_entity_id": "core:nejm",
        "other_entity_in_atlas": true,
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        "evidence": {
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          "locator": "Bibliographic record: journal"
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    ],
    "incoming": [
      {
        "predicate": "results_reported_in",
        "label": "Reports results of",
        "clinical_claim_not_fact": false,
        "family": "sourced",
        "other_entity_id": "cardio:ischemia-trial",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": {
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          "locator": "Abstract, CONCLUSIONS, trailing note"
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    ]
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  "page_path": "publications/pub-ischemia-nejm-2020/",
  "context_path": "api/v1/context/cardio--pub-ischemia-nejm-2020.md"
}