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  "id": "cardio:pub-bplttc-lancet-2021",
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  "kind": "publication",
  "slug": "pub-bplttc-lancet-2021",
  "name": "BPLTTC individual-participant meta-analysis, Lancet 2021",
  "aliases": [
    "Blood Pressure Lowering Treatment Trialists' Collaboration 2021"
  ],
  "atlases": [
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  "summary_plain": "A large analysis that pooled the original patient-level data from 48 randomised trials of blood-pressure-lowering medicines, 344,716 people in all. It asked whether the medicines lower the risk of strokes, heart attacks and heart failure both in people who have already had a stroke, a heart attack or ischaemic heart disease and in people who have not, and at different starting blood pressures. The authors report a similar proportional benefit in both groups.",
  "summary_technical": "The Blood Pressure Lowering Treatment Trialists' Collaboration. Lancet 2021;397(10285):1625-1636. doi:10.1016/S0140-6736(21)00590-0. PMID 33933205. PMC8102467 (open access, CC BY 4.0). PubMed type: Meta-Analysis. A one-stage individual-participant analysis with stratified Cox proportional hazard models; the primary outcome is a major cardiovascular event. This page is a publication record, not a study: it links none of the trials it pools. The one erratum (doi:10.1016/S0140-6736(21)01069-2, PMID 34022983) only updates the collaboration group list. Figure 3 (component outcomes, including stroke alone) is an image that was not read, so no component result is recorded.",
  "editorial_state": "draft",
  "last_substantive_edit": "2026-10-11",
  "last_evidence_check": null,
  "next_review_due": null,
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      "namespace": "doi",
      "value": "10.1016/S0140-6736(21)00590-0"
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      "value": "33933205"
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      "namespace": "pmcid",
      "value": "PMC8102467"
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  "navigation": {
    "cardio": {
      "condition-area": [
        "hypertension",
        "risk-and-prevention"
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    "publication_type": "article",
    "plain_interpretation": "The authors read the result as saying that the proportional benefit followed the size of the blood pressure fall, whether or not a person already had a stroke, heart attack or ischaemic heart disease, and even at normal or high-normal readings. That is the authors' interpretation. It has not been independently assessed here."
  },
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}