{
  "release_id": "5dcd9b263fe17744",
  "id": "cardio:mitral-regurgitation",
  "owner": "cardio",
  "kind": "condition",
  "slug": "mitral-regurgitation",
  "name": "Mitral regurgitation",
  "aliases": [
    "Mitral valve insufficiency",
    "Leaky mitral valve",
    "Secondary mitral regurgitation",
    "Functional mitral regurgitation"
  ],
  "atlases": [
    "cardio"
  ],
  "summary_plain": "Mitral regurgitation means the valve between the left upper and lower heart chambers does not close tightly, so some blood leaks backward. A US government patient page says the leak is most often due to prolapse, where the valve flaps sag back. In people with heart failure the leak can be due to weakness of the left lower chamber (left ventricular dysfunction); trials call this secondary or functional mitral regurgitation. Medicines, a repair or a replacement can treat it, and a US government treatment page lists a device placed through a catheter among the options for people for whom open-heart surgery is not advised.",
  "summary_technical": "MeSH D008944 is named Mitral Valve Insufficiency. The registry record for COAPT lists the condition as mitral regurgitation, and its abstract describes patients with heart failure and moderate-to-severe or severe secondary mitral regurgitation who stayed symptomatic despite maximal doses of guideline-directed medical therapy. US approvals for the MitraClip device cover degenerative mitral regurgitation at prohibitive surgical risk (2013) and secondary mitral regurgitation (2019). Secondary mitral regurgitation also relates to heart failure, and this record links to the heart failure record for that reason.",
  "editorial_state": "draft",
  "last_substantive_edit": "2026-10-15",
  "last_evidence_check": "2026-10-14",
  "next_review_due": null,
  "identifiers": [
    {
      "scheme": "mesh",
      "value": "D008944",
      "normalized_value": "D008944",
      "match": "exact",
      "version": "linked-data record read 2026-10-14",
      "label": null,
      "from_source": false
    }
  ],
  "navigation": {
    "cardio": {
      "system": [
        "heart"
      ],
      "condition-area": [
        "valvular-and-congenital-disease",
        "heart-failure"
      ]
    }
  },
  "payload": {
    "recognition": "A US government patient page says a doctor may diagnose a valve problem from symptoms, by listening to the heart or with imaging tests.",
    "assessment": null,
    "burden_claims": []
  },
  "content_digest": "c2e3209fb28fed97ea1e842ca448cee9ff00690d543cf97d6aae9fbb3b257baa",
  "review": {
    "content_digest": "c2e3209fb28fed97ea1e842ca448cee9ff00690d543cf97d6aae9fbb3b257baa",
    "current": [],
    "conflicting": [],
    "stale": [],
    "inactive": []
  },
  "claims": [],
  "decisions": [],
  "milestones": [],
  "relationships": {
    "outgoing": [
      {
        "predicate": "subtype_of",
        "label": "A leak of the mitral valve",
        "clinical_claim_not_fact": false,
        "family": "navigation",
        "other_entity_id": "cardio:heart-valve-disease",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": null,
        "primary": true,
        "role": null,
        "valid_from": null,
        "valid_to": null
      },
      {
        "predicate": "related_to",
        "label": "Related to heart failure",
        "clinical_claim_not_fact": false,
        "family": "navigation",
        "other_entity_id": "cardio:heart-failure",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": null,
        "primary": false,
        "role": null,
        "valid_from": null,
        "valid_to": null
      },
      {
        "predicate": "part_of",
        "label": "Filed under this front",
        "clinical_claim_not_fact": false,
        "family": "navigation",
        "other_entity_id": "cardio:front-procedures-and-surgery",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": null,
        "primary": true,
        "role": null,
        "valid_from": null,
        "valid_to": null
      }
    ],
    "incoming": [
      {
        "predicate": "evaluated_for",
        "label": "Evaluated for this",
        "clinical_claim_not_fact": true,
        "family": "clinical",
        "other_entity_id": "cardio:mitraclip",
        "other_entity_in_atlas": true,
        "claim_id": "cardio:claim-coapt-hf-hospitalization",
        "evidence": null,
        "primary": false,
        "role": null,
        "valid_from": null,
        "valid_to": null
      },
      {
        "predicate": "evaluated_for",
        "label": "Evaluated for this",
        "clinical_claim_not_fact": true,
        "family": "clinical",
        "other_entity_id": "cardio:mitraclip",
        "other_entity_in_atlas": true,
        "claim_id": "cardio:claim-coapt-all-cause-death",
        "evidence": null,
        "primary": false,
        "role": null,
        "valid_from": null,
        "valid_to": null
      },
      {
        "predicate": "investigates",
        "label": "Investigated in",
        "clinical_claim_not_fact": false,
        "family": "sourced",
        "other_entity_id": "cardio:coapt",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": {
          "snapshot_id": "cardio:ctgov-nct01626079-2026-10-14",
          "locator": "protocolSection.conditionsModule.conditions[0]"
        },
        "primary": false,
        "role": null,
        "valid_from": null,
        "valid_to": null
      },
      {
        "predicate": "related_to",
        "label": "Related to",
        "clinical_claim_not_fact": false,
        "family": "navigation",
        "other_entity_id": "cardio:transcatheter-edge-to-edge-repair",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": null,
        "primary": false,
        "role": null,
        "valid_from": null,
        "valid_to": null
      }
    ]
  },
  "page_path": "conditions/mitral-regurgitation/",
  "context_path": "api/v1/context/cardio--mitral-regurgitation.md"
}