{
  "release_id": "5dcd9b263fe17744",
  "id": "cardio:mineralocorticoid-receptor-antagonists",
  "owner": "cardio",
  "kind": "drug",
  "slug": "mineralocorticoid-receptor-antagonists",
  "name": "Mineralocorticoid receptor antagonists (drug class)",
  "aliases": [
    "Aldosterone antagonists"
  ],
  "atlases": [
    "cardio"
  ],
  "summary_plain": "A class of medicines that includes the aldosterone antagonists, such as spironolactone. A US government patient page groups aldosterone antagonists with diuretics as medicines that clear excess salt and water from the body, which reduces the volume of blood the heart has to pump. It names them among the medicines commonly used for the reduced type of heart failure, and it lists kidney problems and a high blood potassium level among their possible side effects.",
  "summary_technical": "Class page for the mineralocorticoid receptor antagonists. The source is a US government treatment page, last updated 2022-03-24, which names spironolactone as an example and does not mention blood tests; follow-up blood tests are not stated here. The MeSH heading D000451 is an exact match. One member substance, finerenone, is recorded; no other is.",
  "editorial_state": "draft",
  "last_substantive_edit": "2026-10-15",
  "last_evidence_check": "2026-10-14",
  "next_review_due": null,
  "identifiers": [
    {
      "scheme": "mesh",
      "value": "D000451",
      "normalized_value": "D000451",
      "match": "exact",
      "version": "read 2026-10-14",
      "label": null,
      "from_source": false
    }
  ],
  "navigation": {
    "cardio": {
      "system": [
        "heart"
      ],
      "condition-area": [
        "heart-failure"
      ]
    }
  },
  "payload": {
    "level": "class",
    "mechanism": "A US government patient page says aldosterone antagonists clear excess salt and water from the body, which reduces the volume of blood the heart has to pump."
  },
  "content_digest": "65a157bae7c1972096505fdede2f2f31bcf83d65beec690f12a74edccc28b041",
  "review": {
    "content_digest": "65a157bae7c1972096505fdede2f2f31bcf83d65beec690f12a74edccc28b041",
    "current": [],
    "conflicting": [],
    "stale": [],
    "inactive": []
  },
  "claims": [],
  "decisions": [],
  "milestones": [],
  "relationships": {
    "outgoing": [
      {
        "predicate": "part_of",
        "label": "Files under this front",
        "clinical_claim_not_fact": false,
        "family": "navigation",
        "other_entity_id": "cardio:front-medicines",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": null,
        "primary": true,
        "role": null,
        "valid_from": null,
        "valid_to": null
      }
    ],
    "incoming": [
      {
        "predicate": "subtype_of",
        "label": "Has subtype",
        "clinical_claim_not_fact": false,
        "family": "sourced",
        "other_entity_id": "cardio:finerenone",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": {
          "snapshot_id": "cardio:rxclass-2562811-2026-10-14",
          "locator": "rxclassDrugInfoList.rxclassDrugInfo[0].rxclassMinConceptItem.className"
        },
        "primary": true,
        "role": null,
        "valid_from": null,
        "valid_to": null
      }
    ]
  },
  "page_path": "drugs/mineralocorticoid-receptor-antagonists/",
  "context_path": "api/v1/context/cardio--mineralocorticoid-receptor-antagonists.md"
}