{
  "release_id": "f6f6f1b6f50379ed",
  "id": "cardio:fourier",
  "owner": "cardio",
  "kind": "study",
  "slug": "fourier",
  "name": "FOURIER (evolocumab in people with cardiovascular disease)",
  "aliases": [
    "FOURIER",
    "Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk"
  ],
  "atlases": [
    "cardio"
  ],
  "summary_plain": "A large trial of 27,564 people with atherosclerotic cardiovascular disease and raised LDL cholesterol who already took a statin. Half also received evolocumab, an injected PCSK9 antibody, and half received placebo. Evolocumab lowered LDL cholesterol and reduced heart and blood-vessel events over a median of 2.2 years.",
  "summary_technical": "Phase 3, randomized, double-blind, placebo-controlled trial (NCT01764633), 27,564 participants enrolled, started 2013-02-08 and primary completion 2016-11-11. The abstract reports the primary composite in 9.8% against 11.3% (hazard ratio 0.85, 95% CI 0.79 to 0.92). The paper says it was funded by Amgen, the registry lead sponsor. The registry lists dyslipidemia as the condition.",
  "editorial_state": "draft",
  "last_substantive_edit": "2026-10-15",
  "last_evidence_check": "2026-10-14",
  "next_review_due": null,
  "identifiers": [
    {
      "scheme": "nct",
      "value": "NCT01764633",
      "normalized_value": "NCT01764633",
      "match": "exact",
      "version": null,
      "label": null,
      "from_source": false
    }
  ],
  "navigation": {
    "cardio": {
      "condition-area": [
        "coronary-and-vascular-disease"
      ]
    }
  },
  "payload": {
    "design": "Allocation: randomized. Intervention model: parallel. Masking: quadruple. Primary purpose: treatment. (Registry values, in lower case.)",
    "drug_phase": "3",
    "registry_statuses": [
      {
        "status": "COMPLETED",
        "snapshot": "cardio:ctgov-nct01764633-2026-10-14"
      }
    ],
    "start_date": {
      "date": "2013-02-08",
      "type": "actual",
      "snapshot": "cardio:ctgov-nct01764633-2026-10-14"
    },
    "primary_completion_date": {
      "date": "2016-11-11",
      "type": "actual",
      "snapshot": "cardio:ctgov-nct01764633-2026-10-14"
    },
    "completion_date": {
      "date": "2016-11-11",
      "type": "actual",
      "snapshot": "cardio:ctgov-nct01764633-2026-10-14"
    },
    "results_first_posted": {
      "date": "2018-02-15",
      "type": "actual",
      "snapshot": "cardio:ctgov-nct01764633-2026-10-14"
    },
    "countries": [
      {
        "code": "US",
        "snapshot": "cardio:ctgov-nct01764633-2026-10-14"
      },
      {
        "code": "AR",
        "snapshot": "cardio:ctgov-nct01764633-2026-10-14"
      },
      {
        "code": "AU",
        "snapshot": "cardio:ctgov-nct01764633-2026-10-14"
      },
      {
        "code": "AT",
        "snapshot": "cardio:ctgov-nct01764633-2026-10-14"
      },
      {
        "code": "BE",
        "snapshot": "cardio:ctgov-nct01764633-2026-10-14"
      },
      {
        "code": "BR",
        "snapshot": "cardio:ctgov-nct01764633-2026-10-14"
      },
      {
        "code": "BG",
        "snapshot": "cardio:ctgov-nct01764633-2026-10-14"
      },
      {
        "code": "CA",
        "snapshot": "cardio:ctgov-nct01764633-2026-10-14"
      },
      {
        "code": "CL",
        "snapshot": "cardio:ctgov-nct01764633-2026-10-14"
      },
      {
        "code": "CN",
        "snapshot": "cardio:ctgov-nct01764633-2026-10-14"
      },
      {
        "code": "CO",
        "snapshot": "cardio:ctgov-nct01764633-2026-10-14"
      },
      {
        "code": "CZ",
        "snapshot": "cardio:ctgov-nct01764633-2026-10-14"
      },
      {
        "code": "DK",
        "snapshot": "cardio:ctgov-nct01764633-2026-10-14"
      },
      {
        "code": "EE",
        "snapshot": "cardio:ctgov-nct01764633-2026-10-14"
      },
      {
        "code": "FI",
        "snapshot": "cardio:ctgov-nct01764633-2026-10-14"
      },
      {
        "code": "FR",
        "snapshot": "cardio:ctgov-nct01764633-2026-10-14"
      },
      {
        "code": "DE",
        "snapshot": "cardio:ctgov-nct01764633-2026-10-14"
      },
      {
        "code": "GR",
        "snapshot": "cardio:ctgov-nct01764633-2026-10-14"
      },
      {
        "code": "HU",
        "snapshot": "cardio:ctgov-nct01764633-2026-10-14"
      },
      {
        "code": "IS",
        "snapshot": "cardio:ctgov-nct01764633-2026-10-14"
      },
      {
        "code": "IN",
        "snapshot": "cardio:ctgov-nct01764633-2026-10-14"
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      {
        "code": "IE",
        "snapshot": "cardio:ctgov-nct01764633-2026-10-14"
      },
      {
        "code": "IL",
        "snapshot": "cardio:ctgov-nct01764633-2026-10-14"
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      {
        "code": "IT",
        "snapshot": "cardio:ctgov-nct01764633-2026-10-14"
      },
      {
        "code": "JP",
        "snapshot": "cardio:ctgov-nct01764633-2026-10-14"
      },
      {
        "code": "LV",
        "snapshot": "cardio:ctgov-nct01764633-2026-10-14"
      },
      {
        "code": "LT",
        "snapshot": "cardio:ctgov-nct01764633-2026-10-14"
      },
      {
        "code": "MY",
        "snapshot": "cardio:ctgov-nct01764633-2026-10-14"
      },
      {
        "code": "MX",
        "snapshot": "cardio:ctgov-nct01764633-2026-10-14"
      },
      {
        "code": "NL",
        "snapshot": "cardio:ctgov-nct01764633-2026-10-14"
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      {
        "code": "NZ",
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        "code": "NO",
        "snapshot": "cardio:ctgov-nct01764633-2026-10-14"
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      {
        "code": "PH",
        "snapshot": "cardio:ctgov-nct01764633-2026-10-14"
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        "code": "PL",
        "snapshot": "cardio:ctgov-nct01764633-2026-10-14"
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        "code": "PT",
        "snapshot": "cardio:ctgov-nct01764633-2026-10-14"
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        "code": "SG",
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        "code": "SK",
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      {
        "code": "ZA",
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        "snapshot": "cardio:ctgov-nct01764633-2026-10-14"
      },
      {
        "code": "CH",
        "snapshot": "cardio:ctgov-nct01764633-2026-10-14"
      },
      {
        "code": "TW",
        "snapshot": "cardio:ctgov-nct01764633-2026-10-14"
      },
      {
        "code": "UA",
        "snapshot": "cardio:ctgov-nct01764633-2026-10-14"
      },
      {
        "code": "GB",
        "snapshot": "cardio:ctgov-nct01764633-2026-10-14"
      },
      {
        "code": "HK",
        "snapshot": "cardio:ctgov-nct01764633-2026-10-14"
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      {
        "code": "TR",
        "snapshot": "cardio:ctgov-nct01764633-2026-10-14"
      }
    ],
    "care_setting": null,
    "stopped_early": null,
    "enrollment": [
      {
        "count": 27564,
        "basis": "enrolled",
        "unit": "participants",
        "snapshot": "cardio:ctgov-nct01764633-2026-10-14"
      }
    ],
    "arms": [
      {
        "id": "cardio:fourier-arm-1",
        "label": "Placebo",
        "intervention": null,
        "description": "Participants received placebo subcutaneous injections either once every 2 weeks (Q2W) or once a month (QM) according to their own preference."
      },
      {
        "id": "cardio:fourier-arm-2",
        "label": "Evolocumab",
        "intervention": null,
        "description": "Participants received evolocumab 140 mg Q2W or 420 mg QM subcutaneous injections according to their own preference."
      }
    ],
    "findings": []
  },
  "content_digest": "ffad9f7025cc112224e6880179a9095fa86dbe6d780c4d9114e5f860853b9d56",
  "review": {
    "content_digest": "ffad9f7025cc112224e6880179a9095fa86dbe6d780c4d9114e5f860853b9d56",
    "current": [],
    "conflicting": [],
    "stale": [],
    "inactive": []
  },
  "claims": [],
  "decisions": [],
  "milestones": [],
  "relationships": {
    "outgoing": [
      {
        "predicate": "investigates",
        "label": "Tests evolocumab",
        "clinical_claim_not_fact": false,
        "family": "sourced",
        "other_entity_id": "cardio:evolocumab",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": {
          "snapshot_id": "cardio:ctgov-nct01764633-2026-10-14",
          "locator": "protocolSection.armsInterventionsModule.interventions[0].name"
        },
        "primary": false,
        "role": null,
        "valid_from": null,
        "valid_to": null
      },
      {
        "predicate": "investigates",
        "label": "Official title names the effect of additional LDL cholesterol reduction",
        "clinical_claim_not_fact": false,
        "family": "sourced",
        "other_entity_id": "cardio:ldl-cholesterol",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": {
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          "locator": "protocolSection.identificationModule.officialTitle"
        },
        "primary": false,
        "role": null,
        "valid_from": null,
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      }
    ],
    "incoming": []
  },
  "page_path": "studies/fourier/",
  "context_path": "api/v1/context/cardio--fourier.md"
}