{
  "release_id": "f6f6f1b6f50379ed",
  "id": "cardio:ezetimibe",
  "owner": "cardio",
  "kind": "drug",
  "slug": "ezetimibe",
  "name": "Ezetimibe",
  "aliases": [
    "Zetia"
  ],
  "atlases": [
    "cardio"
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  "summary_plain": "Ezetimibe is a cholesterol pill that is not a statin. It works by reducing how much cholesterol the gut absorbs. In IMPROVE-IT, adding it to a statin after an acute coronary syndrome lowered LDL cholesterol further and gave a small extra reduction in heart and blood-vessel events.",
  "summary_technical": "RxNorm ingredient 341248. The IMPROVE-IT abstract describes it as a nonstatin drug that reduces intestinal cholesterol absorption. The evidence recorded is the combination with simvastatin; ezetimibe alone is not tested in this atlas.",
  "editorial_state": "draft",
  "last_substantive_edit": "2026-10-14",
  "last_evidence_check": "2026-10-14",
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  "identifiers": [
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      "version": null,
      "label": null,
      "from_source": false
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  "navigation": {
    "cardio": {
      "condition-area": [
        "coronary-and-vascular-disease"
      ]
    }
  },
  "payload": {
    "level": "substance",
    "mechanism": "Reduces intestinal cholesterol absorption (IMPROVE-IT abstract)"
  },
  "content_digest": "3ebc25dddaa588e0a0b4f5eb7df4e71b858427850ebdb5b02086433c2a338065",
  "review": {
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    "current": [],
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    "inactive": []
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      "owner": "cardio",
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      "category": "effect",
      "statement": "In IMPROVE-IT, 18,144 patients hospitalised for an acute coronary syndrome in the previous 10 days received simvastatin 40 mg with ezetimibe 10 mg or simvastatin 40 mg with placebo. The median time-weighted LDL cholesterol was 53.7 mg/dL with ezetimibe added and 69.5 mg/dL with simvastatin alone. At 7 years the Kaplan-Meier rate of the primary composite end point was 32.7% with ezetimibe and 34.7% with simvastatin alone (absolute difference 2.0 percentage points; hazard ratio 0.936, 95% CI 0.89 to 0.99; P=0.016). The abstract says muscle, gallbladder and hepatic adverse effects and cancer were similar in the two groups.",
      "context": {
        "id": "cardio:ctx-improve-it-acs-adults",
        "label": "Adults hospitalised for an acute coronary syndrome in the previous 10 days with LDL cholesterol 50 to 100 mg/dL on lipid-lowering therapy (IMPROVE-IT)",
        "recipient": "adult",
        "population": "Patients hospitalised for an acute coronary syndrome within the preceding 10 days, with LDL cholesterol 50 to 100 mg/dL if on lipid-lowering therapy or 50 to 125 mg/dL if not (abstract). The registry gives a minimum age of 18 years and all sexes.",
        "care_setting": "Hospital-recruited patients followed in a multicentre trial (abstract). Site list not read.",
        "geography": "Not stated in the source (abstract). The registry record lists no countries.",
        "life_stage_note": "Adult, 18 years and older (registry minimum age)",
        "life_stage_terms": null,
        "gestational_age_min_days": null,
        "gestational_age_max_days": null,
        "gestational_age_basis": null,
        "postnatal_age_min_days": null,
        "postnatal_age_max_days": null,
        "gestational_age_status": null,
        "postnatal_age_status": null,
        "followup_description": "Median follow-up 6 years (abstract). The registry gives up to approximately 9 years as the outcome time frame.",
        "eligibility": {
          "inclusion": [
            "Hospitalised for an acute coronary syndrome in the preceding 10 days",
            "LDL cholesterol 50 to 100 mg per deciliter if receiving lipid-lowering therapy, or 50 to 125 mg per deciliter if not (abstract)"
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          "exclusion": []
        }
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      "evidence_stage": "interventional",
      "certainty": "not_assessed",
      "certainty_method": null,
      "limitations": "One randomised trial, double-blind, funded by Merck according to the abstract. The benefit is modest in absolute terms (2.0 percentage points at 7 years). The population was people after an acute coronary syndrome who took simvastatin 40 mg; the result is for adding ezetimibe to that statin, not for ezetimibe alone. Abstract only; the registry record lists Organon and Co as its current lead sponsor.",
      "editorial_state": "draft",
      "checked_at": "2026-10-14",
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