{
  "release_id": "f6f6f1b6f50379ed",
  "id": "cardio:dapa-hf",
  "owner": "cardio",
  "kind": "study",
  "slug": "dapa-hf",
  "name": "DAPA-HF",
  "aliases": [
    "Dapagliflozin and heart failure with reduced ejection fraction trial"
  ],
  "atlases": [
    "cardio"
  ],
  "summary_plain": "A large trial in adults with heart failure and a reduced ejection fraction (40% or less) who were already taking recommended treatment. About half were given dapagliflozin 10 mg once a day and half a placebo. Over a median of about 18 months, fewer people on dapagliflozin had worsening heart failure or died from cardiovascular causes. The authors report similar findings in people with and without diabetes.",
  "summary_technical": "AstraZeneca-sponsored, randomized, placebo-controlled phase 3 trial (NCT03036124) of 4744 patients with NYHA class II to IV heart failure and an ejection fraction of 40% or less. Primary outcome: worsening heart failure (hospitalization or an urgent visit with intravenous therapy) or cardiovascular death, hazard ratio 0.74 (95% CI 0.65 to 0.85) over a median of 18.2 months, from the PubMed abstract. The full text was not read. The registry holds a results section that this record does not extract. Funding is stated in the abstract as AstraZeneca.",
  "editorial_state": "draft",
  "last_substantive_edit": "2026-10-14",
  "last_evidence_check": "2026-10-14",
  "next_review_due": null,
  "identifiers": [
    {
      "scheme": "nct",
      "value": "NCT03036124",
      "normalized_value": "NCT03036124",
      "match": "exact",
      "version": null,
      "label": null,
      "from_source": false
    }
  ],
  "navigation": {
    "cardio": {
      "system": [
        "heart"
      ],
      "condition-area": [
        "heart-failure"
      ]
    }
  },
  "payload": {
    "design": "Randomized, parallel-group, placebo-controlled phase 3 trial of dapagliflozin 10 mg once daily added to recommended therapy. The registry records masking as quadruple and the primary purpose as treatment.",
    "drug_phase": "3",
    "registry_statuses": [
      {
        "status": "COMPLETED",
        "snapshot": "cardio:ctgov-nct03036124-2026-10-14"
      }
    ],
    "start_date": {
      "date": "2017-02-08",
      "type": "actual",
      "snapshot": "cardio:ctgov-nct03036124-2026-10-14"
    },
    "primary_completion_date": {
      "date": "2019-07-17",
      "type": "actual",
      "snapshot": "cardio:ctgov-nct03036124-2026-10-14"
    },
    "completion_date": {
      "date": "2019-07-17",
      "type": "actual",
      "snapshot": "cardio:ctgov-nct03036124-2026-10-14"
    },
    "results_first_posted": {
      "date": "2020-09-01",
      "type": "actual",
      "snapshot": "cardio:ctgov-nct03036124-2026-10-14"
    },
    "countries": [
      {
        "code": "US",
        "snapshot": "cardio:ctgov-nct03036124-2026-10-14"
      },
      {
        "code": "AR",
        "snapshot": "cardio:ctgov-nct03036124-2026-10-14"
      },
      {
        "code": "BR",
        "snapshot": "cardio:ctgov-nct03036124-2026-10-14"
      },
      {
        "code": "BG",
        "snapshot": "cardio:ctgov-nct03036124-2026-10-14"
      },
      {
        "code": "CA",
        "snapshot": "cardio:ctgov-nct03036124-2026-10-14"
      },
      {
        "code": "CN",
        "snapshot": "cardio:ctgov-nct03036124-2026-10-14"
      },
      {
        "code": "CZ",
        "snapshot": "cardio:ctgov-nct03036124-2026-10-14"
      },
      {
        "code": "DK",
        "snapshot": "cardio:ctgov-nct03036124-2026-10-14"
      },
      {
        "code": "DE",
        "snapshot": "cardio:ctgov-nct03036124-2026-10-14"
      },
      {
        "code": "HU",
        "snapshot": "cardio:ctgov-nct03036124-2026-10-14"
      },
      {
        "code": "IN",
        "snapshot": "cardio:ctgov-nct03036124-2026-10-14"
      },
      {
        "code": "JP",
        "snapshot": "cardio:ctgov-nct03036124-2026-10-14"
      },
      {
        "code": "NL",
        "snapshot": "cardio:ctgov-nct03036124-2026-10-14"
      },
      {
        "code": "PL",
        "snapshot": "cardio:ctgov-nct03036124-2026-10-14"
      },
      {
        "code": "RU",
        "snapshot": "cardio:ctgov-nct03036124-2026-10-14"
      },
      {
        "code": "SK",
        "snapshot": "cardio:ctgov-nct03036124-2026-10-14"
      },
      {
        "code": "SE",
        "snapshot": "cardio:ctgov-nct03036124-2026-10-14"
      },
      {
        "code": "TW",
        "snapshot": "cardio:ctgov-nct03036124-2026-10-14"
      },
      {
        "code": "GB",
        "snapshot": "cardio:ctgov-nct03036124-2026-10-14"
      },
      {
        "code": "VN",
        "snapshot": "cardio:ctgov-nct03036124-2026-10-14"
      }
    ],
    "care_setting": null,
    "stopped_early": null,
    "enrollment": [
      {
        "count": 4744,
        "basis": "randomized",
        "unit": "patients",
        "snapshot": "cardio:pubmed-31535829-2026-10-14"
      }
    ],
    "arms": [
      {
        "id": "cardio:dapa-hf-arm-dapagliflozin",
        "label": "Dapagliflozin",
        "intervention": "cardio:dapagliflozin",
        "description": "Dapagliflozin 10 mg once daily, added to recommended therapy (abstract). The registry says patients were randomized 1:1 to dapagliflozin or placebo."
      },
      {
        "id": "cardio:dapa-hf-arm-placebo",
        "label": "Placebo",
        "intervention": null,
        "description": "Placebo matching dapagliflozin, added to recommended therapy (registry and abstract)."
      }
    ],
    "findings": []
  },
  "content_digest": "1a0f83d314a7ad8d89c66ac1caf76d721ddbf9be0f99b9f83455b26f5f8b7445",
  "review": {
    "content_digest": "1a0f83d314a7ad8d89c66ac1caf76d721ddbf9be0f99b9f83455b26f5f8b7445",
    "current": [],
    "conflicting": [],
    "stale": [],
    "inactive": []
  },
  "claims": [],
  "decisions": [],
  "milestones": [],
  "relationships": {
    "outgoing": [
      {
        "predicate": "investigates",
        "label": "Tests this medicine",
        "clinical_claim_not_fact": false,
        "family": "sourced",
        "other_entity_id": "cardio:dapagliflozin",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": {
          "snapshot_id": "cardio:ctgov-nct03036124-2026-10-14",
          "locator": "protocolSection.armsInterventionsModule.interventions[0].name"
        },
        "primary": false,
        "role": null,
        "valid_from": null,
        "valid_to": null
      },
      {
        "predicate": "investigates",
        "label": "Studies people with this condition",
        "clinical_claim_not_fact": false,
        "family": "sourced",
        "other_entity_id": "cardio:hfref",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": {
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          "locator": "protocolSection.conditionsModule.conditions[0]"
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        "primary": false,
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      },
      {
        "predicate": "sponsored_by",
        "label": "Lead sponsor on the registry record",
        "clinical_claim_not_fact": false,
        "family": "sourced",
        "other_entity_id": "cardio:astrazeneca",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": {
          "snapshot_id": "cardio:ctgov-nct03036124-2026-10-14",
          "locator": "protocolSection.sponsorCollaboratorsModule.leadSponsor.name"
        },
        "primary": false,
        "role": "lead",
        "valid_from": null,
        "valid_to": null
      }
    ],
    "incoming": []
  },
  "page_path": "studies/dapa-hf/",
  "context_path": "api/v1/context/cardio--dapa-hf.md"
}