{
  "release_id": "5dcd9b263fe17744",
  "id": "cardio:dapa-ckd",
  "owner": "cardio",
  "kind": "study",
  "slug": "dapa-ckd",
  "name": "DAPA-CKD: dapagliflozin in chronic kidney disease",
  "aliases": [
    "DAPA-CKD"
  ],
  "atlases": [
    "cardio"
  ],
  "summary_plain": "A large trial of people with chronic kidney disease, with or without type 2 diabetes. Half took dapagliflozin 10 mg a day and half took placebo. The monitoring committee recommended stopping the trial early because dapagliflozin was working. It lowered the risk of kidney failure, a large fall in kidney function, or death from a kidney or heart cause, and the effect was similar with and without diabetes.",
  "summary_technical": "Randomized, double-blind, placebo-controlled trial sponsored by AstraZeneca (NCT03036150). 4304 participants with an eGFR of 25 to 75 and a urinary albumin-to-creatinine ratio of 200 to 5000. Median follow-up 2.4 years. Primary outcome (sustained eGFR decline of at least 50%, end-stage kidney disease, or death from renal or cardiovascular causes): 197 of 2152 (9.2%) against 312 of 2152 (14.5%), hazard ratio 0.61 (95% CI 0.51 to 0.72; P<0.001).",
  "editorial_state": "draft",
  "last_substantive_edit": "2026-10-15",
  "last_evidence_check": null,
  "next_review_due": null,
  "identifiers": [
    {
      "scheme": "nct",
      "value": "NCT03036150",
      "normalized_value": "NCT03036150",
      "match": "exact",
      "version": null,
      "label": null,
      "from_source": false
    }
  ],
  "navigation": {
    "cardio": {
      "system": [
        "kidneys"
      ],
      "condition-area": [
        "kidney-connections"
      ]
    }
  },
  "payload": {
    "design": "Randomized, double-blind, placebo-controlled, parallel-group trial. The registry records phase 3 and quadruple masking.",
    "drug_phase": "3",
    "registry_statuses": [
      {
        "status": "COMPLETED",
        "snapshot": "cardio:ctgov-nct03036150-2026-10-14"
      }
    ],
    "start_date": {
      "date": "2017-02-02",
      "type": "actual",
      "snapshot": "cardio:ctgov-nct03036150-2026-10-14"
    },
    "primary_completion_date": {
      "date": "2020-06-12",
      "type": "actual",
      "snapshot": "cardio:ctgov-nct03036150-2026-10-14"
    },
    "completion_date": {
      "date": "2020-06-12",
      "type": "actual",
      "snapshot": "cardio:ctgov-nct03036150-2026-10-14"
    },
    "results_first_posted": {
      "date": "2021-07-07",
      "type": "actual",
      "snapshot": "cardio:ctgov-nct03036150-2026-10-14"
    },
    "countries": [
      {
        "code": "US",
        "snapshot": "cardio:ctgov-nct03036150-2026-10-14"
      },
      {
        "code": "AR",
        "snapshot": "cardio:ctgov-nct03036150-2026-10-14"
      },
      {
        "code": "BR",
        "snapshot": "cardio:ctgov-nct03036150-2026-10-14"
      },
      {
        "code": "CA",
        "snapshot": "cardio:ctgov-nct03036150-2026-10-14"
      },
      {
        "code": "CN",
        "snapshot": "cardio:ctgov-nct03036150-2026-10-14"
      },
      {
        "code": "DK",
        "snapshot": "cardio:ctgov-nct03036150-2026-10-14"
      },
      {
        "code": "DE",
        "snapshot": "cardio:ctgov-nct03036150-2026-10-14"
      },
      {
        "code": "HU",
        "snapshot": "cardio:ctgov-nct03036150-2026-10-14"
      },
      {
        "code": "IN",
        "snapshot": "cardio:ctgov-nct03036150-2026-10-14"
      },
      {
        "code": "JP",
        "snapshot": "cardio:ctgov-nct03036150-2026-10-14"
      },
      {
        "code": "MX",
        "snapshot": "cardio:ctgov-nct03036150-2026-10-14"
      },
      {
        "code": "PE",
        "snapshot": "cardio:ctgov-nct03036150-2026-10-14"
      },
      {
        "code": "PH",
        "snapshot": "cardio:ctgov-nct03036150-2026-10-14"
      },
      {
        "code": "PL",
        "snapshot": "cardio:ctgov-nct03036150-2026-10-14"
      },
      {
        "code": "RU",
        "snapshot": "cardio:ctgov-nct03036150-2026-10-14"
      },
      {
        "code": "KR",
        "snapshot": "cardio:ctgov-nct03036150-2026-10-14"
      },
      {
        "code": "ES",
        "snapshot": "cardio:ctgov-nct03036150-2026-10-14"
      },
      {
        "code": "SE",
        "snapshot": "cardio:ctgov-nct03036150-2026-10-14"
      },
      {
        "code": "UA",
        "snapshot": "cardio:ctgov-nct03036150-2026-10-14"
      },
      {
        "code": "GB",
        "snapshot": "cardio:ctgov-nct03036150-2026-10-14"
      },
      {
        "code": "VN",
        "snapshot": "cardio:ctgov-nct03036150-2026-10-14"
      }
    ],
    "care_setting": null,
    "stopped_early": {
      "scope": "trial",
      "date": null,
      "reason": "The independent data monitoring committee recommended stopping the trial because of efficacy. The registry records the study as completed.",
      "snapshot": "cardio:pubmed-32970396-2026-10-14"
    },
    "enrollment": [
      {
        "count": 4304,
        "basis": "enrolled",
        "unit": "participants",
        "snapshot": "cardio:ctgov-nct03036150-2026-10-14"
      }
    ],
    "arms": [
      {
        "id": "cardio:dapa-ckd-arm-dapagliflozin",
        "label": "Dapagliflozin",
        "intervention": null,
        "description": "Dapagliflozin 10 mg once daily."
      },
      {
        "id": "cardio:dapa-ckd-arm-placebo",
        "label": "Placebo",
        "intervention": null,
        "description": "Placebo."
      }
    ],
    "findings": []
  },
  "content_digest": "ba3a65752a52aa2247d9e2c08502216003cc6ce2ad77f783fb43ab860b64f3e6",
  "review": {
    "content_digest": "ba3a65752a52aa2247d9e2c08502216003cc6ce2ad77f783fb43ab860b64f3e6",
    "current": [],
    "conflicting": [],
    "stale": [],
    "inactive": []
  },
  "claims": [],
  "decisions": [],
  "milestones": [],
  "relationships": {
    "outgoing": [
      {
        "predicate": "investigates",
        "label": "Lists chronic kidney disease as its condition",
        "clinical_claim_not_fact": false,
        "family": "sourced",
        "other_entity_id": "cardio:chronic-kidney-disease",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": {
          "snapshot_id": "cardio:ctgov-nct03036150-2026-10-14",
          "locator": "protocolSection.conditionsModule.conditions[0]"
        },
        "primary": false,
        "role": null,
        "valid_from": null,
        "valid_to": null
      },
      {
        "predicate": "sponsored_by",
        "label": "Lead sponsor on the registry record",
        "clinical_claim_not_fact": false,
        "family": "sourced",
        "other_entity_id": "cardio:astrazeneca",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": {
          "snapshot_id": "cardio:ctgov-nct03036150-2026-10-14",
          "locator": "protocolSection.sponsorCollaboratorsModule.leadSponsor.name"
        },
        "primary": false,
        "role": "lead",
        "valid_from": null,
        "valid_to": null
      },
      {
        "predicate": "investigates",
        "label": "Tests this medicine",
        "clinical_claim_not_fact": false,
        "family": "sourced",
        "other_entity_id": "cardio:dapagliflozin",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": {
          "snapshot_id": "cardio:ctgov-nct03036150-2026-10-14",
          "locator": "protocolSection.armsInterventionsModule.interventions[0].name"
        },
        "primary": false,
        "role": null,
        "valid_from": null,
        "valid_to": null
      },
      {
        "predicate": "investigates",
        "label": "Names a sustained eGFR decline in its primary outcome",
        "clinical_claim_not_fact": false,
        "family": "sourced",
        "other_entity_id": "cardio:egfr",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": {
          "snapshot_id": "cardio:ctgov-nct03036150-2026-10-14",
          "locator": "protocolSection.outcomesModule.primaryOutcomes[0].measure"
        },
        "primary": false,
        "role": null,
        "valid_from": null,
        "valid_to": null
      }
    ],
    "incoming": []
  },
  "page_path": "studies/dapa-ckd/",
  "context_path": "api/v1/context/cardio--dapa-ckd.md"
}