{ "release_id": "f6f6f1b6f50379ed", "id": "cardio:colchicine", "owner": "cardio", "kind": "drug", "slug": "colchicine", "name": "Colchicine", "aliases": [], "atlases": [ "cardio" ], "summary_plain": "Colchicine is an old medicine, best known for gout, that has anti-inflammatory effects. In the LoDoCo2 trial, a low daily dose lowered the rate of heart and blood-vessel events in people with chronic coronary disease, though deaths from non-cardiovascular causes were reported at a higher rate with colchicine, with an interval that includes no difference.", "summary_technical": "RxNorm ingredient 2683. The LoDoCo2 abstract tested 0.5 mg once daily. The registry record of a separate trial, COLCOT (NCT02551094), lists coronary artery disease and myocardial infarction as conditions and was committed as a source; its results are not recorded here.", "editorial_state": "draft", "last_substantive_edit": "2026-10-14", "last_evidence_check": "2026-10-14", "next_review_due": null, "identifiers": [ { "scheme": "rxnorm", "value": "2683", "normalized_value": "2683", "match": "exact", "version": null, "label": null, "from_source": false } ], "navigation": { "cardio": { "condition-area": [ "coronary-and-vascular-disease" ] } }, "payload": { "level": "substance", "mechanism": "Anti-inflammatory effects (LoDoCo2 abstract); the abstract gives no further mechanism" }, "content_digest": "c999d5d071e913fd0ef500f59d67550f3cf8bf494fb3ceaa324fbf7bd0419a5e", "review": { "content_digest": "c999d5d071e913fd0ef500f59d67550f3cf8bf494fb3ceaa324fbf7bd0419a5e", "current": [], "conflicting": [], "stale": [], "inactive": [] }, "claims": [ { "release_id": "f6f6f1b6f50379ed", "id": "cardio:claim-lodoco2-low-dose-colchicine", "owner": "cardio", "subject_entity_id": "cardio:colchicine", "category": "effect", "statement": "In LoDoCo2, 5522 patients with chronic coronary disease were randomised to colchicine 0.5 mg once daily (2762) or placebo (2760). Over a median of 28.6 months, the primary composite end point occurred in 187 patients (6.8%) on colchicine and 264 (9.6%) on placebo (2.5 against 3.6 events per 100 person-years; hazard ratio 0.69, 95% CI 0.57 to 0.83). The key secondary composite occurred in 115 (4.2%) and 157 (5.7%) (hazard ratio 0.72, 95% CI 0.57 to 0.92). Death from noncardiovascular causes was higher with colchicine (0.7 against 0.5 events per 100 person-years; hazard ratio 1.51, 95% CI 0.99 to 2.31).", "context": { "id": "cardio:ctx-lodoco2-chronic-coronary-disease", "label": "Patients with chronic coronary disease (LoDoCo2)", "recipient": "adult", "population": "Patients with chronic coronary disease; 5522 were randomised (abstract). The abstract does not give an age range. The trial is registered with the Australian New Zealand Clinical Trials Registry, which was not read.", "care_setting": "Not stated in the source (abstract only)", "geography": "Not stated in the source (abstract only)", "life_stage_note": "Adult patients; no age range is stated in the abstract", "life_stage_terms": null, "gestational_age_min_days": null, "gestational_age_max_days": null, "gestational_age_basis": null, "postnatal_age_min_days": null, "postnatal_age_max_days": null, "gestational_age_status": null, "postnatal_age_status": null, "followup_description": "Median follow-up 28.6 months (abstract).", "eligibility": { "inclusion": [ "Chronic coronary disease" ], "exclusion": [] } }, "evidence_stage": "interventional", "certainty": "not_assessed", "certainty_method": null, "limitations": "One randomised, double-blind trial; the abstract names the National Health Medical Research Council of Australia and others as funders. The higher rate of noncardiovascular death is reported as given and its interval includes 1. This record covers LoDoCo2 only. A separate trial of colchicine after a recent heart attack is registered as COLCOT (NCT02551094); this atlas records its registry entry and not its results. Abstract only.", "editorial_state": "draft", "checked_at": "2026-10-14", "next_review_due": null, "valid_from": null, "valid_to": null, "citations": [ { "evidence_role": "supports", "locator": "Abstract, RESULTS, sentence 1: \"A total of 5522 patients underwent randomization; 2762 were assigned to the colchicine group and 2760 to the placebo group.\"", "applicability_note": "Abstract of the paper from PubMed; the full text was not read.", "snapshot": { "id": "cardio:pubmed-32865380-2026-10-14", "retrieved_at": "2026-10-14T18:18:41Z", "content_hash": "ddd2ae03d4ef00e0ec60f3605e8bbcff12e505f23739010ac34d3a85292c96e6", "source_effective_date": null, "public_archive_url": null, "source_state": "current" }, "source": { "id": "cardio:pubmed-10-1056-nejmoa2021372", "source_type": "publication", "title": "Colchicine in Patients with Chronic Coronary Disease", "canonical_url": "https://doi.org/10.1056/NEJMoa2021372", "identifiers": [ { "scheme": "doi", "value": "10.1056/NEJMoa2021372", "normalized_value": "10.1056/nejmoa2021372", "match": "exact", "version": null, "label": null, "from_source": false }, { "scheme": "pmid", "value": "32865380", "normalized_value": "32865380", "match": "exact", "version": null, "label": null, "from_source": false } ], "publication_date": "2020-11-05", "publisher": "The New England journal of medicine", "edition": "PubMed record (abstract and bibliographic data) from NCBI E-utilities. The full text and the version of record were not fetched.", "reuse_basis": "PubMed record fetched through NCBI E-utilities. Only the hash of the bytes is kept, because publisher copyright may apply to the abstract (https://pubmed.ncbi.nlm.nih.gov/disclaimer/). Short factual quotations under 25 words, with the citation.", "public_text": "quote" } }, { "evidence_role": "supports", "locator": "Abstract, METHODS, sentence 1: \"In a randomized, controlled, double-blind trial, we assigned patients with chronic coronary disease to receive 0.5 mg of colchicine once daily or matching placebo.\"", "applicability_note": "Dose and comparator.", "snapshot": { "id": "cardio:pubmed-32865380-2026-10-14", "retrieved_at": "2026-10-14T18:18:41Z", "content_hash": "ddd2ae03d4ef00e0ec60f3605e8bbcff12e505f23739010ac34d3a85292c96e6", "source_effective_date": null, "public_archive_url": null, "source_state": "current" }, "source": { "id": "cardio:pubmed-10-1056-nejmoa2021372", "source_type": "publication", "title": "Colchicine in Patients with Chronic Coronary Disease", "canonical_url": "https://doi.org/10.1056/NEJMoa2021372", "identifiers": [ { "scheme": "doi", "value": "10.1056/NEJMoa2021372", "normalized_value": "10.1056/nejmoa2021372", "match": "exact", "version": null, "label": null, "from_source": false }, { "scheme": "pmid", "value": "32865380", "normalized_value": "32865380", "match": "exact", "version": null, "label": null, "from_source": false } ], "publication_date": "2020-11-05", "publisher": "The New England journal of medicine", "edition": "PubMed record (abstract and bibliographic data) from NCBI E-utilities. The full text and the version of record were not fetched.", "reuse_basis": "PubMed record fetched through NCBI E-utilities. Only the hash of the bytes is kept, because publisher copyright may apply to the abstract (https://pubmed.ncbi.nlm.nih.gov/disclaimer/). Short factual quotations under 25 words, with the citation.", "public_text": "quote" } }, { "evidence_role": "supports", "locator": "Abstract, METHODS, sentence 2: \"The primary end point was a composite of cardiovascular death, spontaneous (nonprocedural) myocardial infarction, ischemic stroke, or ischemia-driven coronary revascularization.\"", "applicability_note": "Primary end point.", "snapshot": { "id": "cardio:pubmed-32865380-2026-10-14", "retrieved_at": "2026-10-14T18:18:41Z", "content_hash": "ddd2ae03d4ef00e0ec60f3605e8bbcff12e505f23739010ac34d3a85292c96e6", "source_effective_date": null, "public_archive_url": null, "source_state": "current" }, "source": { "id": "cardio:pubmed-10-1056-nejmoa2021372", "source_type": "publication", "title": "Colchicine in Patients with Chronic Coronary Disease", "canonical_url": "https://doi.org/10.1056/NEJMoa2021372", "identifiers": [ { "scheme": "doi", "value": "10.1056/NEJMoa2021372", "normalized_value": "10.1056/nejmoa2021372", "match": "exact", "version": null, "label": null, "from_source": false }, { "scheme": "pmid", "value": "32865380", "normalized_value": "32865380", "match": "exact", "version": null, "label": null, "from_source": false } ], "publication_date": "2020-11-05", "publisher": "The New England journal of medicine", "edition": "PubMed record (abstract and bibliographic data) from NCBI E-utilities. The full text and the version of record were not fetched.", "reuse_basis": "PubMed record fetched through NCBI E-utilities. Only the hash of the bytes is kept, because publisher copyright may apply to the abstract (https://pubmed.ncbi.nlm.nih.gov/disclaimer/). Short factual quotations under 25 words, with the citation.", "public_text": "quote" } }, { "evidence_role": "supports", "locator": "Abstract, METHODS, sentence 3: \"The key secondary end point was a composite of cardiovascular death, spontaneous myocardial infarction, or ischemic stroke.\"", "applicability_note": "Key secondary end point.", "snapshot": { "id": "cardio:pubmed-32865380-2026-10-14", "retrieved_at": "2026-10-14T18:18:41Z", "content_hash": "ddd2ae03d4ef00e0ec60f3605e8bbcff12e505f23739010ac34d3a85292c96e6", "source_effective_date": null, "public_archive_url": null, "source_state": "current" }, "source": { "id": "cardio:pubmed-10-1056-nejmoa2021372", "source_type": "publication", "title": "Colchicine in Patients with Chronic Coronary Disease", "canonical_url": "https://doi.org/10.1056/NEJMoa2021372", "identifiers": [ { "scheme": "doi", "value": "10.1056/NEJMoa2021372", "normalized_value": "10.1056/nejmoa2021372", "match": "exact", "version": null, "label": null, "from_source": false }, { "scheme": "pmid", "value": "32865380", "normalized_value": "32865380", "match": "exact", "version": null, "label": null, "from_source": false } ], "publication_date": "2020-11-05", "publisher": "The New England journal of medicine", "edition": "PubMed record (abstract and bibliographic data) from NCBI E-utilities. The full text and the version of record were not fetched.", "reuse_basis": "PubMed record fetched through NCBI E-utilities. Only the hash of the bytes is kept, because publisher copyright may apply to the abstract (https://pubmed.ncbi.nlm.nih.gov/disclaimer/). Short factual quotations under 25 words, with the citation.", "public_text": "quote" } }, { "evidence_role": "supports", "locator": "Abstract, RESULTS, sentence 2: \"The median duration of follow-up was 28.6 months.\"", "applicability_note": "Median follow-up.", "snapshot": { "id": "cardio:pubmed-32865380-2026-10-14", "retrieved_at": "2026-10-14T18:18:41Z", "content_hash": "ddd2ae03d4ef00e0ec60f3605e8bbcff12e505f23739010ac34d3a85292c96e6", "source_effective_date": null, "public_archive_url": null, "source_state": "current" }, "source": { "id": "cardio:pubmed-10-1056-nejmoa2021372", "source_type": "publication", "title": "Colchicine in Patients with Chronic Coronary Disease", "canonical_url": "https://doi.org/10.1056/NEJMoa2021372", "identifiers": [ { "scheme": "doi", "value": "10.1056/NEJMoa2021372", "normalized_value": "10.1056/nejmoa2021372", "match": "exact", "version": null, "label": null, "from_source": false }, { "scheme": "pmid", "value": "32865380", "normalized_value": "32865380", "match": "exact", "version": null, "label": null, "from_source": false } ], "publication_date": "2020-11-05", "publisher": "The New England journal of medicine", "edition": "PubMed record (abstract and bibliographic data) from NCBI E-utilities. The full text and the version of record were not fetched.", "reuse_basis": "PubMed record fetched through NCBI E-utilities. Only the hash of the bytes is kept, because publisher copyright may apply to the abstract (https://pubmed.ncbi.nlm.nih.gov/disclaimer/). Short factual quotations under 25 words, with the citation.", "public_text": "quote" } }, { "evidence_role": "supports", "locator": "Abstract, RESULTS, sentence 3, fragment 1 of 2: \"A primary end-point event occurred in 187 patients (6.8%) in the colchicine group and in 264 patients (9.6%) in the placebo group (incidence,\"", "applicability_note": "Primary end point counts.", "snapshot": { "id": "cardio:pubmed-32865380-2026-10-14", "retrieved_at": "2026-10-14T18:18:41Z", "content_hash": "ddd2ae03d4ef00e0ec60f3605e8bbcff12e505f23739010ac34d3a85292c96e6", "source_effective_date": null, "public_archive_url": null, "source_state": "current" }, "source": { "id": "cardio:pubmed-10-1056-nejmoa2021372", "source_type": "publication", "title": "Colchicine in Patients with Chronic Coronary Disease", "canonical_url": "https://doi.org/10.1056/NEJMoa2021372", "identifiers": [ { "scheme": "doi", "value": "10.1056/NEJMoa2021372", "normalized_value": "10.1056/nejmoa2021372", "match": "exact", "version": null, "label": null, "from_source": false }, { "scheme": "pmid", "value": "32865380", "normalized_value": "32865380", "match": "exact", "version": null, "label": null, "from_source": false } ], "publication_date": "2020-11-05", "publisher": "The New England journal of medicine", "edition": "PubMed record (abstract and bibliographic data) from NCBI E-utilities. The full text and the version of record were not fetched.", "reuse_basis": "PubMed record fetched through NCBI E-utilities. Only the hash of the bytes is kept, because publisher copyright may apply to the abstract (https://pubmed.ncbi.nlm.nih.gov/disclaimer/). Short factual quotations under 25 words, with the citation.", "public_text": "quote" } }, { "evidence_role": "supports", "locator": "Abstract, RESULTS, sentence 3, fragment 2 of 2: \"2.5 vs. 3.6 events per 100 person-years; hazard ratio, 0.69; 95% confidence interval [CI], 0.57 to 0.83; P<0.001).\"", "applicability_note": "Primary end point rates and hazard ratio.", "snapshot": { "id": "cardio:pubmed-32865380-2026-10-14", "retrieved_at": "2026-10-14T18:18:41Z", "content_hash": "ddd2ae03d4ef00e0ec60f3605e8bbcff12e505f23739010ac34d3a85292c96e6", "source_effective_date": null, "public_archive_url": null, "source_state": "current" }, "source": { "id": "cardio:pubmed-10-1056-nejmoa2021372", "source_type": "publication", "title": "Colchicine in Patients with Chronic Coronary Disease", "canonical_url": "https://doi.org/10.1056/NEJMoa2021372", "identifiers": [ { "scheme": "doi", "value": "10.1056/NEJMoa2021372", "normalized_value": "10.1056/nejmoa2021372", "match": "exact", "version": null, "label": null, "from_source": false }, { "scheme": "pmid", "value": "32865380", "normalized_value": "32865380", "match": "exact", "version": null, "label": null, "from_source": false } ], "publication_date": "2020-11-05", "publisher": "The New England journal of medicine", "edition": "PubMed record (abstract and bibliographic data) from NCBI E-utilities. The full text and the version of record were not fetched.", "reuse_basis": "PubMed record fetched through NCBI E-utilities. Only the hash of the bytes is kept, because publisher copyright may apply to the abstract (https://pubmed.ncbi.nlm.nih.gov/disclaimer/). Short factual quotations under 25 words, with the citation.", "public_text": "quote" } }, { "evidence_role": "supports", "locator": "Abstract, RESULTS, sentence 4, fragment 1 of 2: \"A key secondary end-point event occurred in 115 patients (4.2%) in the colchicine group and in 157 patients (5.7%) in the placebo group (incidence,\"", "applicability_note": "Key secondary counts.", "snapshot": { "id": "cardio:pubmed-32865380-2026-10-14", "retrieved_at": "2026-10-14T18:18:41Z", "content_hash": "ddd2ae03d4ef00e0ec60f3605e8bbcff12e505f23739010ac34d3a85292c96e6", "source_effective_date": null, "public_archive_url": null, "source_state": "current" }, "source": { "id": "cardio:pubmed-10-1056-nejmoa2021372", "source_type": "publication", "title": "Colchicine in Patients with Chronic Coronary Disease", "canonical_url": "https://doi.org/10.1056/NEJMoa2021372", "identifiers": [ { "scheme": "doi", "value": "10.1056/NEJMoa2021372", "normalized_value": "10.1056/nejmoa2021372", "match": "exact", "version": null, "label": null, "from_source": false }, { "scheme": "pmid", "value": "32865380", "normalized_value": "32865380", "match": "exact", "version": null, "label": null, "from_source": false } ], "publication_date": "2020-11-05", "publisher": "The New England journal of medicine", "edition": "PubMed record (abstract and bibliographic data) from NCBI E-utilities. The full text and the version of record were not fetched.", "reuse_basis": "PubMed record fetched through NCBI E-utilities. Only the hash of the bytes is kept, because publisher copyright may apply to the abstract (https://pubmed.ncbi.nlm.nih.gov/disclaimer/). Short factual quotations under 25 words, with the citation.", "public_text": "quote" } }, { "evidence_role": "supports", "locator": "Abstract, RESULTS, sentence 4, fragment 2 of 2: \"1.5 vs. 2.1 events per 100 person-years; hazard ratio, 0.72; 95% CI, 0.57 to 0.92; P = 0.007).\"", "applicability_note": "Key secondary hazard ratio.", "snapshot": { "id": "cardio:pubmed-32865380-2026-10-14", "retrieved_at": "2026-10-14T18:18:41Z", "content_hash": "ddd2ae03d4ef00e0ec60f3605e8bbcff12e505f23739010ac34d3a85292c96e6", "source_effective_date": null, "public_archive_url": null, "source_state": "current" }, "source": { "id": "cardio:pubmed-10-1056-nejmoa2021372", "source_type": "publication", "title": "Colchicine in Patients with Chronic Coronary Disease", "canonical_url": "https://doi.org/10.1056/NEJMoa2021372", "identifiers": [ { "scheme": "doi", "value": "10.1056/NEJMoa2021372", "normalized_value": "10.1056/nejmoa2021372", "match": "exact", "version": null, "label": null, "from_source": false }, { "scheme": "pmid", "value": "32865380", "normalized_value": "32865380", "match": "exact", "version": null, "label": null, "from_source": false } ], "publication_date": "2020-11-05", "publisher": "The New England journal of medicine", "edition": "PubMed record (abstract and bibliographic data) from NCBI E-utilities. The full text and the version of record were not fetched.", "reuse_basis": "PubMed record fetched through NCBI E-utilities. Only the hash of the bytes is kept, because publisher copyright may apply to the abstract (https://pubmed.ncbi.nlm.nih.gov/disclaimer/). Short factual quotations under 25 words, with the citation.", "public_text": "quote" } }, { "evidence_role": "supports", "locator": "Abstract, RESULTS, sentence 6, fragment 1 of 2: \"The incidence of death from noncardiovascular causes was higher in the colchicine group than in the placebo group (incidence,\"", "applicability_note": "Noncardiovascular death, rates.", "snapshot": { "id": "cardio:pubmed-32865380-2026-10-14", "retrieved_at": "2026-10-14T18:18:41Z", "content_hash": "ddd2ae03d4ef00e0ec60f3605e8bbcff12e505f23739010ac34d3a85292c96e6", "source_effective_date": null, "public_archive_url": null, "source_state": "current" }, "source": { "id": "cardio:pubmed-10-1056-nejmoa2021372", "source_type": "publication", "title": "Colchicine in Patients with Chronic Coronary Disease", "canonical_url": "https://doi.org/10.1056/NEJMoa2021372", "identifiers": [ { "scheme": "doi", "value": "10.1056/NEJMoa2021372", "normalized_value": "10.1056/nejmoa2021372", "match": "exact", "version": null, "label": null, "from_source": false }, { "scheme": "pmid", "value": "32865380", "normalized_value": "32865380", "match": "exact", "version": null, "label": null, "from_source": false } ], "publication_date": "2020-11-05", "publisher": "The New England journal of medicine", "edition": "PubMed record (abstract and bibliographic data) from NCBI E-utilities. The full text and the version of record were not fetched.", "reuse_basis": "PubMed record fetched through NCBI E-utilities. Only the hash of the bytes is kept, because publisher copyright may apply to the abstract (https://pubmed.ncbi.nlm.nih.gov/disclaimer/). Short factual quotations under 25 words, with the citation.", "public_text": "quote" } }, { "evidence_role": "supports", "locator": "Abstract, RESULTS, sentence 6, fragment 2 of 2: \"0.7 vs. 0.5 events per 100 person-years; hazard ratio, 1.51; 95% CI, 0.99 to 2.31).\"", "applicability_note": "Noncardiovascular death, hazard ratio.", "snapshot": { "id": "cardio:pubmed-32865380-2026-10-14", "retrieved_at": "2026-10-14T18:18:41Z", "content_hash": "ddd2ae03d4ef00e0ec60f3605e8bbcff12e505f23739010ac34d3a85292c96e6", "source_effective_date": null, "public_archive_url": null, "source_state": "current" }, "source": { "id": "cardio:pubmed-10-1056-nejmoa2021372", "source_type": "publication", "title": "Colchicine in Patients with Chronic Coronary Disease", "canonical_url": "https://doi.org/10.1056/NEJMoa2021372", "identifiers": [ { "scheme": "doi", "value": "10.1056/NEJMoa2021372", "normalized_value": "10.1056/nejmoa2021372", "match": "exact", "version": null, "label": null, "from_source": false }, { "scheme": "pmid", "value": "32865380", "normalized_value": "32865380", "match": "exact", "version": null, "label": null, "from_source": false } ], "publication_date": "2020-11-05", "publisher": "The New England journal of medicine", "edition": "PubMed record (abstract and bibliographic data) from NCBI E-utilities. The full text and the version of record were not fetched.", "reuse_basis": "PubMed record fetched through NCBI E-utilities. Only the hash of the bytes is kept, because publisher copyright may apply to the abstract (https://pubmed.ncbi.nlm.nih.gov/disclaimer/). Short factual quotations under 25 words, with the citation.", "public_text": "quote" } }, { "evidence_role": "context", "locator": "Abstract, BACKGROUND, sentence 1, fragment 1 of 2: \"Evidence from a recent trial has shown that the antiinflammatory effects of colchicine reduce the risk of cardiovascular events in patients with recent myocardial\"", "applicability_note": "Background: an earlier trial in recent myocardial infarction.", "snapshot": { "id": "cardio:pubmed-32865380-2026-10-14", "retrieved_at": "2026-10-14T18:18:41Z", "content_hash": "ddd2ae03d4ef00e0ec60f3605e8bbcff12e505f23739010ac34d3a85292c96e6", "source_effective_date": null, "public_archive_url": null, "source_state": "current" }, "source": { "id": "cardio:pubmed-10-1056-nejmoa2021372", "source_type": "publication", "title": "Colchicine in Patients with Chronic Coronary Disease", "canonical_url": "https://doi.org/10.1056/NEJMoa2021372", "identifiers": [ { "scheme": "doi", "value": "10.1056/NEJMoa2021372", "normalized_value": "10.1056/nejmoa2021372", "match": "exact", "version": null, "label": null, "from_source": false }, { "scheme": "pmid", "value": "32865380", "normalized_value": "32865380", "match": "exact", "version": null, "label": null, "from_source": false } ], "publication_date": "2020-11-05", "publisher": "The New England journal of medicine", "edition": "PubMed record (abstract and bibliographic data) from NCBI E-utilities. The full text and the version of record were not fetched.", "reuse_basis": "PubMed record fetched through NCBI E-utilities. Only the hash of the bytes is kept, because publisher copyright may apply to the abstract (https://pubmed.ncbi.nlm.nih.gov/disclaimer/). Short factual quotations under 25 words, with the citation.", "public_text": "quote" } }, { "evidence_role": "context", "locator": "Abstract, CONCLUSIONS, sentence 2: \"(Funded by the National Health Medical Research Council of Australia and others; LoDoCo2 Australian New Zealand Clinical Trials Registry number, ACTRN12614000093684.).\"", "applicability_note": "Funding and registry note in the abstract.", "snapshot": { "id": "cardio:pubmed-32865380-2026-10-14", "retrieved_at": "2026-10-14T18:18:41Z", "content_hash": "ddd2ae03d4ef00e0ec60f3605e8bbcff12e505f23739010ac34d3a85292c96e6", "source_effective_date": null, "public_archive_url": null, "source_state": "current" }, "source": { "id": "cardio:pubmed-10-1056-nejmoa2021372", "source_type": "publication", "title": "Colchicine in Patients with Chronic Coronary Disease", "canonical_url": "https://doi.org/10.1056/NEJMoa2021372", "identifiers": [ { "scheme": "doi", "value": "10.1056/NEJMoa2021372", "normalized_value": "10.1056/nejmoa2021372", "match": "exact", "version": null, "label": null, "from_source": false }, { "scheme": "pmid", "value": "32865380", "normalized_value": "32865380", "match": "exact", "version": null, "label": null, "from_source": false } ], "publication_date": "2020-11-05", "publisher": "The New England journal of medicine", "edition": "PubMed record (abstract and bibliographic data) from NCBI E-utilities. The full text and the version of record were not fetched.", "reuse_basis": "PubMed record fetched through NCBI E-utilities. Only the hash of the bytes is kept, because publisher copyright may apply to the abstract (https://pubmed.ncbi.nlm.nih.gov/disclaimer/). Short factual quotations under 25 words, with the citation.", "public_text": "quote" } }, { "evidence_role": "context", "locator": "protocolSection.identificationModule.officialTitle: \"Colchicine Cardiovascular Outcomes Trial (COLCOT)\"", "applicability_note": "COLCOT registry record exists; its results are not recorded here.", "snapshot": { "id": "cardio:ctgov-nct02551094-2026-10-14", "retrieved_at": "2026-10-14T18:18:41Z", "content_hash": "853218a89e798bbb4547b5b565e25641d6bb71af58d65795257862c561df8e5b", "source_effective_date": "2020-10-19", "public_archive_url": null, "source_state": "current" }, "source": { "id": "cardio:ctgov-nct02551094", "source_type": "registry", "title": "Colchicine Cardiovascular Outcomes Trial (COLCOT)", "canonical_url": "https://clinicaltrials.gov/study/NCT02551094", "identifiers": [ { "scheme": "nct", "value": "NCT02551094", "normalized_value": "NCT02551094", "match": "exact", "version": null, "label": null, "from_source": false } ], "publication_date": null, "publisher": "U.S. National Library of Medicine (ClinicalTrials.gov)", "edition": "ClinicalTrials.gov API v2 record, last update posted 2020-10-19.", "reuse_basis": "Registry record. The raw API JSON is committed. The ClinicalTrials.gov terms page is rendered by JavaScript and its text was not read by a script, so the redistribution basis is unverified; any quotation stays short. The raw file is committed at research/snapshots/cg-ctgov-NCT02551094.json.", "public_text": "quote" } }, { "evidence_role": "context", "locator": "protocolSection.conditionsModule.conditions[1]: \"Myocardial Infarction\"", "applicability_note": "COLCOT lists myocardial infarction as a condition.", "snapshot": { "id": "cardio:ctgov-nct02551094-2026-10-14", "retrieved_at": "2026-10-14T18:18:41Z", "content_hash": "853218a89e798bbb4547b5b565e25641d6bb71af58d65795257862c561df8e5b", "source_effective_date": "2020-10-19", "public_archive_url": null, "source_state": "current" }, "source": { "id": "cardio:ctgov-nct02551094", "source_type": "registry", "title": "Colchicine Cardiovascular Outcomes Trial (COLCOT)", "canonical_url": "https://clinicaltrials.gov/study/NCT02551094", "identifiers": [ { "scheme": "nct", "value": "NCT02551094", "normalized_value": "NCT02551094", "match": "exact", "version": null, "label": null, "from_source": false } ], "publication_date": null, "publisher": "U.S. National Library of Medicine (ClinicalTrials.gov)", "edition": "ClinicalTrials.gov API v2 record, last update posted 2020-10-19.", "reuse_basis": "Registry record. The raw API JSON is committed. The ClinicalTrials.gov terms page is rendered by JavaScript and its text was not read by a script, so the redistribution basis is unverified; any quotation stays short. The raw file is committed at research/snapshots/cg-ctgov-NCT02551094.json.", "public_text": "quote" } } ], "review": { "content_digest": "21f013e18166c856f80112069b8728490e3f610e98da0a4ef60b6c0f307f56bf", "current": [], "conflicting": [], "stale": [], "inactive": [] }, "api_path": "api/v1/claims/cardio--claim-lodoco2-low-dose-colchicine.json" } ], "decisions": [], "milestones": [], "relationships": { "outgoing": [ { "predicate": "evaluated_for", "label": "Fewer events in chronic coronary disease at low dose", "clinical_claim_not_fact": true, "family": "clinical", "other_entity_id": "cardio:coronary-artery-disease", "other_entity_in_atlas": true, "claim_id": "cardio:claim-lodoco2-low-dose-colchicine", "evidence": null, "primary": false, "role": null, "valid_from": null, "valid_to": null }, { "predicate": "part_of", "label": "Files under this front", "clinical_claim_not_fact": false, "family": "navigation", "other_entity_id": "cardio:front-medicines", "other_entity_in_atlas": true, "claim_id": null, "evidence": null, "primary": true, "role": null, "valid_from": null, "valid_to": null } ], "incoming": [] }, "page_path": "drugs/colchicine/", "context_path": "api/v1/context/cardio--colchicine.md" }