{
  "release_id": "f6f6f1b6f50379ed",
  "id": "cardio:chronic-kidney-disease",
  "owner": "cardio",
  "kind": "condition",
  "slug": "chronic-kidney-disease",
  "name": "Chronic kidney disease (CKD)",
  "aliases": [
    "CKD",
    "Chronic renal insufficiency"
  ],
  "atlases": [
    "cardio"
  ],
  "summary_plain": "A long-term condition in which the kidneys are damaged and cannot filter the blood the way they should. Diabetes and high blood pressure are the most common causes in adults. Many people have no symptoms until the disease is far along, and blood and urine tests are the way to find it.",
  "summary_technical": "Hub condition for the kidney outcome trials in this atlas: FLOW, FIDELIO-DKD, DAPA-CKD and EMPA-KIDNEY. It is found and followed with the eGFR blood test and the urine albumin-to-creatinine ratio (UACR).",
  "editorial_state": "draft",
  "last_substantive_edit": "2026-10-14",
  "last_evidence_check": null,
  "next_review_due": null,
  "identifiers": [
    {
      "scheme": "mesh",
      "value": "D051436",
      "normalized_value": "D051436",
      "match": "exact",
      "version": "2026",
      "label": null,
      "from_source": false
    }
  ],
  "navigation": {
    "cardio": {
      "system": [
        "kidneys"
      ],
      "condition-area": [
        "kidney-connections"
      ]
    }
  },
  "payload": {
    "recognition": "Many people have no symptoms until the kidney disease is very advanced.",
    "assessment": "Blood and urine tests, including eGFR and the urine albumin-to-creatinine ratio, are used to find and follow it.",
    "burden_claims": []
  },
  "content_digest": "e101278cd8b3a4484d45e4396b8f09544705657bdec64eb10577e241d86c5aef",
  "review": {
    "content_digest": "e101278cd8b3a4484d45e4396b8f09544705657bdec64eb10577e241d86c5aef",
    "current": [],
    "conflicting": [],
    "stale": [],
    "inactive": []
  },
  "claims": [],
  "decisions": [],
  "milestones": [],
  "relationships": {
    "outgoing": [
      {
        "predicate": "related_to",
        "label": "NIDDK and MedlinePlus name high blood pressure, with diabetes, as a most common cause of chronic kidney disease in adults",
        "clinical_claim_not_fact": false,
        "family": "navigation",
        "other_entity_id": "core:hypertension",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": null,
        "primary": false,
        "role": null,
        "valid_from": null,
        "valid_to": null
      },
      {
        "predicate": "related_to",
        "label": "Related to heart failure",
        "clinical_claim_not_fact": false,
        "family": "navigation",
        "other_entity_id": "cardio:heart-failure",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": null,
        "primary": false,
        "role": null,
        "valid_from": null,
        "valid_to": null
      },
      {
        "predicate": "part_of",
        "label": "Filed under this front",
        "clinical_claim_not_fact": false,
        "family": "navigation",
        "other_entity_id": "cardio:front-kidney-and-metabolic-care",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": null,
        "primary": true,
        "role": null,
        "valid_from": null,
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      }
    ],
    "incoming": [
      {
        "predicate": "related_to",
        "label": "Related to",
        "clinical_claim_not_fact": false,
        "family": "navigation",
        "other_entity_id": "core:medlineplus",
        "other_entity_in_atlas": true,
        "claim_id": null,
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        "primary": false,
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        "valid_to": null
      },
      {
        "predicate": "evaluated_for",
        "label": "Evaluated for this",
        "clinical_claim_not_fact": true,
        "family": "clinical",
        "other_entity_id": "cardio:egfr",
        "other_entity_in_atlas": true,
        "claim_id": "cardio:claim-egfr-use",
        "evidence": null,
        "primary": false,
        "role": null,
        "valid_from": null,
        "valid_to": null
      },
      {
        "predicate": "evaluated_for",
        "label": "Evaluated for this",
        "clinical_claim_not_fact": true,
        "family": "clinical",
        "other_entity_id": "cardio:uacr",
        "other_entity_in_atlas": true,
        "claim_id": "cardio:claim-uacr-use",
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        "primary": false,
        "role": null,
        "valid_from": null,
        "valid_to": null
      },
      {
        "predicate": "related_to",
        "label": "Related to",
        "clinical_claim_not_fact": false,
        "family": "navigation",
        "other_entity_id": "cardio:cardiovascular-kidney-metabolic-health",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": null,
        "primary": false,
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      },
      {
        "predicate": "increases_risk_of",
        "label": "Risk raised by",
        "clinical_claim_not_fact": true,
        "family": "clinical",
        "other_entity_id": "cardio:type-2-diabetes",
        "other_entity_in_atlas": true,
        "claim_id": "cardio:claim-diabetes-ckd-cause",
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        "valid_from": null,
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      },
      {
        "predicate": "evaluated_for",
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        "other_entity_in_atlas": true,
        "claim_id": "cardio:claim-dapa-ckd-kidney-effect",
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      },
      {
        "predicate": "evaluated_for",
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        "clinical_claim_not_fact": true,
        "family": "clinical",
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        "family": "clinical",
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        "evidence": {
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          "locator": "Abstract, METHODS, sentence 1, fragment 1 of 4"
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    ]
  },
  "page_path": "conditions/chronic-kidney-disease/",
  "context_path": "api/v1/context/cardio--chronic-kidney-disease.md"
}