{
  "release_id": "5dcd9b263fe17744",
  "id": "cardio:cardiac-troponin",
  "owner": "cardio",
  "kind": "biomarker",
  "slug": "cardiac-troponin",
  "name": "Cardiac troponin blood test",
  "aliases": [
    "cTn",
    "Troponin test"
  ],
  "atlases": [
    "cardio"
  ],
  "summary_plain": "A troponin test measures troponin, a protein found in heart muscle cells, in a blood sample. When heart muscle is damaged, troponin leaks into the blood and the level rises, so the test is mainly used to help diagnose a heart attack, usually in the emergency room alongside other heart tests. A higher-than-normal level can also come from other kinds of heart muscle damage, and a first normal result is usually followed by a repeat test within about 12 hours.",
  "summary_technical": "MedlinePlus names two types of troponin that can be measured, troponin I and troponin T, and says either may be used. It says normal blood levels are so low that only the most sensitive tests can measure them, and that increased levels usually do not show up until about 2 to 3 hours after a heart attack begins. The page gives no numeric cut-off. MeSH D014336 (Troponin) is the protein and is stored as a broad match.",
  "editorial_state": "draft",
  "last_substantive_edit": "2026-10-15",
  "last_evidence_check": "2026-10-15",
  "next_review_due": null,
  "identifiers": [
    {
      "scheme": "mesh",
      "value": "D014336",
      "normalized_value": "D014336",
      "match": "broad",
      "version": "id.nlm.nih.gov linked data, retrieved 2026-10-15",
      "label": null,
      "from_source": false
    }
  ],
  "navigation": {
    "cardio": {
      "condition-area": [
        "acute-care-and-long-term-living"
      ]
    }
  },
  "payload": {
    "measure": "Concentration of troponin I or troponin T, proteins released from damaged heart muscle, in a blood sample",
    "assay_context": "Blood test, usually done in the emergency room with other heart tests such as an electrocardiogram; a repeat test within about 12 hours follows a normal first result (MedlinePlus)",
    "interpretation_claims": [
      "cardio:claim-troponin-heart-attack-diagnosis"
    ]
  },
  "content_digest": "b5e10d9e44afa86139d8f8e7346c62321cc27cf7b795622646c6532a638dc8f4",
  "review": {
    "content_digest": "b5e10d9e44afa86139d8f8e7346c62321cc27cf7b795622646c6532a638dc8f4",
    "current": [],
    "conflicting": [],
    "stale": [],
    "inactive": []
  },
  "claims": [
    {
      "release_id": "5dcd9b263fe17744",
      "id": "cardio:claim-troponin-heart-attack-diagnosis",
      "owner": "cardio",
      "subject_entity_id": "cardio:cardiac-troponin",
      "category": "descriptive",
      "statement": "MedlinePlus says a troponin test measures the amount of troponin, a protein found in heart muscle cells, in a blood sample, and that the test is mainly used to help diagnose heart attacks. When heart muscle is damaged, troponin leaks into the blood and the level rises, so results can help confirm heart muscle damage from a heart attack. It adds that higher-than-normal levels are also found in other conditions that damage the heart muscle, so a raised level does not always mean a heart attack. The page says the test is usually done in the emergency room together with other heart tests such as an electrocardiogram, and that a first normal result usually leads to a repeat test within the next 12 hours, because a rise often takes about 2 to 3 hours to show after a heart attack begins.",
      "context": {
        "id": "cardio:ctx-troponin-medlineplus-heart-attack-testing",
        "label": "People with symptoms of a heart attack, as described by the MedlinePlus troponin test page",
        "recipient": "unknown",
        "population": "People who may be having or recently had a heart attack, and people having surgery that could affect the heart. The page describes testing in the emergency room alongside other heart tests.",
        "care_setting": "Hospital emergency room (the page says the test is usually done there).",
        "geography": "Not stated; the page is written for a US audience.",
        "life_stage_note": "The page does not state an age group.",
        "life_stage_terms": null,
        "gestational_age_min_days": null,
        "gestational_age_max_days": null,
        "gestational_age_basis": null,
        "postnatal_age_min_days": null,
        "postnatal_age_max_days": null,
        "gestational_age_status": null,
        "postnatal_age_status": null,
        "followup_description": "Not applicable (patient information page).",
        "eligibility": {
          "inclusion": [
            "A blood sample, usually taken in the emergency room"
          ],
          "exclusion": []
        }
      },
      "evidence_stage": "unknown",
      "certainty": "not_assessed",
      "certainty_method": null,
      "limitations": "General patient information from a National Library of Medicine page; it is not an individual care plan and it gives no numeric cut-off. The page does not mention assay generations or high-sensitivity assays by name; it says only that normal levels are so low that only the most sensitive tests can measure them. This claim does not describe any named product.",
      "editorial_state": "draft",
      "checked_at": "2026-10-15",
      "next_review_due": null,
      "valid_from": null,
      "valid_to": null,
      "citations": [
        {
          "evidence_role": "supports",
          "locator": "What is a troponin test?",
          "applicability_note": "Patient information page, restated in the claim.",
          "snapshot": {
            "id": "cardio:medlineplus-troponin-test-2026-10-15",
            "retrieved_at": "2026-10-15T13:53:26Z",
            "content_hash": "8cedb341bb33f49a54cbd378b43cb92518b65288e0182f3cfd9965371909cc6c",
            "source_effective_date": null,
            "public_archive_url": null,
            "source_state": "current"
          },
          "source": {
            "id": "cardio:medlineplus-troponin-test",
            "source_type": "webpage",
            "title": "Troponin Test (MedlinePlus medical test)",
            "canonical_url": "https://medlineplus.gov/lab-tests/troponin-test/",
            "identifiers": [],
            "publication_date": null,
            "publisher": "U.S. National Library of Medicine (MedlinePlus)",
            "edition": "Page fetched 2026-10-15.",
            "reuse_basis": "MedlinePlus states that works produced by the federal government are not copyrighted, and lists the summaries on health topic pages and medical test information as public domain (the page titled Linking to and Using Content from MedlinePlus, fetched as ck-medlineplus-usingcontent.html, sha256 f70c0b8c67574e30377aab0c22b44038364a37e2e9f54a2ffa67597383b3de34). It names the A.D.A.M. encyclopedia, drug monographs and many images as copyrighted; this atlas uses only the page summary text. Source: MedlinePlus, National Library of Medicine. The raw page is committed at research/snapshots/ck-medlineplus-troponin-test.html (fetched as ck-medlineplus-troponin-test.html).",
            "public_text": "quote"
          }
        },
        {
          "evidence_role": "supports",
          "locator": "What is a troponin test? (quote 2)",
          "applicability_note": "Patient information page, restated in the claim.",
          "snapshot": {
            "id": "cardio:medlineplus-troponin-test-2026-10-15",
            "retrieved_at": "2026-10-15T13:53:26Z",
            "content_hash": "8cedb341bb33f49a54cbd378b43cb92518b65288e0182f3cfd9965371909cc6c",
            "source_effective_date": null,
            "public_archive_url": null,
            "source_state": "current"
          },
          "source": {
            "id": "cardio:medlineplus-troponin-test",
            "source_type": "webpage",
            "title": "Troponin Test (MedlinePlus medical test)",
            "canonical_url": "https://medlineplus.gov/lab-tests/troponin-test/",
            "identifiers": [],
            "publication_date": null,
            "publisher": "U.S. National Library of Medicine (MedlinePlus)",
            "edition": "Page fetched 2026-10-15.",
            "reuse_basis": "MedlinePlus states that works produced by the federal government are not copyrighted, and lists the summaries on health topic pages and medical test information as public domain (the page titled Linking to and Using Content from MedlinePlus, fetched as ck-medlineplus-usingcontent.html, sha256 f70c0b8c67574e30377aab0c22b44038364a37e2e9f54a2ffa67597383b3de34). It names the A.D.A.M. encyclopedia, drug monographs and many images as copyrighted; this atlas uses only the page summary text. Source: MedlinePlus, National Library of Medicine. The raw page is committed at research/snapshots/ck-medlineplus-troponin-test.html (fetched as ck-medlineplus-troponin-test.html).",
            "public_text": "quote"
          }
        },
        {
          "evidence_role": "supports",
          "locator": "What is a troponin test? (quote 3)",
          "applicability_note": "Patient information page, restated in the claim.",
          "snapshot": {
            "id": "cardio:medlineplus-troponin-test-2026-10-15",
            "retrieved_at": "2026-10-15T13:53:26Z",
            "content_hash": "8cedb341bb33f49a54cbd378b43cb92518b65288e0182f3cfd9965371909cc6c",
            "source_effective_date": null,
            "public_archive_url": null,
            "source_state": "current"
          },
          "source": {
            "id": "cardio:medlineplus-troponin-test",
            "source_type": "webpage",
            "title": "Troponin Test (MedlinePlus medical test)",
            "canonical_url": "https://medlineplus.gov/lab-tests/troponin-test/",
            "identifiers": [],
            "publication_date": null,
            "publisher": "U.S. National Library of Medicine (MedlinePlus)",
            "edition": "Page fetched 2026-10-15.",
            "reuse_basis": "MedlinePlus states that works produced by the federal government are not copyrighted, and lists the summaries on health topic pages and medical test information as public domain (the page titled Linking to and Using Content from MedlinePlus, fetched as ck-medlineplus-usingcontent.html, sha256 f70c0b8c67574e30377aab0c22b44038364a37e2e9f54a2ffa67597383b3de34). It names the A.D.A.M. encyclopedia, drug monographs and many images as copyrighted; this atlas uses only the page summary text. Source: MedlinePlus, National Library of Medicine. The raw page is committed at research/snapshots/ck-medlineplus-troponin-test.html (fetched as ck-medlineplus-troponin-test.html).",
            "public_text": "quote"
          }
        },
        {
          "evidence_role": "supports",
          "locator": "What is a troponin test? (quote 4)",
          "applicability_note": "Patient information page, restated in the claim.",
          "snapshot": {
            "id": "cardio:medlineplus-troponin-test-2026-10-15",
            "retrieved_at": "2026-10-15T13:53:26Z",
            "content_hash": "8cedb341bb33f49a54cbd378b43cb92518b65288e0182f3cfd9965371909cc6c",
            "source_effective_date": null,
            "public_archive_url": null,
            "source_state": "current"
          },
          "source": {
            "id": "cardio:medlineplus-troponin-test",
            "source_type": "webpage",
            "title": "Troponin Test (MedlinePlus medical test)",
            "canonical_url": "https://medlineplus.gov/lab-tests/troponin-test/",
            "identifiers": [],
            "publication_date": null,
            "publisher": "U.S. National Library of Medicine (MedlinePlus)",
            "edition": "Page fetched 2026-10-15.",
            "reuse_basis": "MedlinePlus states that works produced by the federal government are not copyrighted, and lists the summaries on health topic pages and medical test information as public domain (the page titled Linking to and Using Content from MedlinePlus, fetched as ck-medlineplus-usingcontent.html, sha256 f70c0b8c67574e30377aab0c22b44038364a37e2e9f54a2ffa67597383b3de34). It names the A.D.A.M. encyclopedia, drug monographs and many images as copyrighted; this atlas uses only the page summary text. Source: MedlinePlus, National Library of Medicine. The raw page is committed at research/snapshots/ck-medlineplus-troponin-test.html (fetched as ck-medlineplus-troponin-test.html).",
            "public_text": "quote"
          }
        },
        {
          "evidence_role": "supports",
          "locator": "What is a troponin test? (quote 5)",
          "applicability_note": "Patient information page, restated in the claim.",
          "snapshot": {
            "id": "cardio:medlineplus-troponin-test-2026-10-15",
            "retrieved_at": "2026-10-15T13:53:26Z",
            "content_hash": "8cedb341bb33f49a54cbd378b43cb92518b65288e0182f3cfd9965371909cc6c",
            "source_effective_date": null,
            "public_archive_url": null,
            "source_state": "current"
          },
          "source": {
            "id": "cardio:medlineplus-troponin-test",
            "source_type": "webpage",
            "title": "Troponin Test (MedlinePlus medical test)",
            "canonical_url": "https://medlineplus.gov/lab-tests/troponin-test/",
            "identifiers": [],
            "publication_date": null,
            "publisher": "U.S. National Library of Medicine (MedlinePlus)",
            "edition": "Page fetched 2026-10-15.",
            "reuse_basis": "MedlinePlus states that works produced by the federal government are not copyrighted, and lists the summaries on health topic pages and medical test information as public domain (the page titled Linking to and Using Content from MedlinePlus, fetched as ck-medlineplus-usingcontent.html, sha256 f70c0b8c67574e30377aab0c22b44038364a37e2e9f54a2ffa67597383b3de34). It names the A.D.A.M. encyclopedia, drug monographs and many images as copyrighted; this atlas uses only the page summary text. Source: MedlinePlus, National Library of Medicine. The raw page is committed at research/snapshots/ck-medlineplus-troponin-test.html (fetched as ck-medlineplus-troponin-test.html).",
            "public_text": "quote"
          }
        },
        {
          "evidence_role": "supports",
          "locator": "What is a troponin test? (quote 6)",
          "applicability_note": "Patient information page, restated in the claim.",
          "snapshot": {
            "id": "cardio:medlineplus-troponin-test-2026-10-15",
            "retrieved_at": "2026-10-15T13:53:26Z",
            "content_hash": "8cedb341bb33f49a54cbd378b43cb92518b65288e0182f3cfd9965371909cc6c",
            "source_effective_date": null,
            "public_archive_url": null,
            "source_state": "current"
          },
          "source": {
            "id": "cardio:medlineplus-troponin-test",
            "source_type": "webpage",
            "title": "Troponin Test (MedlinePlus medical test)",
            "canonical_url": "https://medlineplus.gov/lab-tests/troponin-test/",
            "identifiers": [],
            "publication_date": null,
            "publisher": "U.S. National Library of Medicine (MedlinePlus)",
            "edition": "Page fetched 2026-10-15.",
            "reuse_basis": "MedlinePlus states that works produced by the federal government are not copyrighted, and lists the summaries on health topic pages and medical test information as public domain (the page titled Linking to and Using Content from MedlinePlus, fetched as ck-medlineplus-usingcontent.html, sha256 f70c0b8c67574e30377aab0c22b44038364a37e2e9f54a2ffa67597383b3de34). It names the A.D.A.M. encyclopedia, drug monographs and many images as copyrighted; this atlas uses only the page summary text. Source: MedlinePlus, National Library of Medicine. The raw page is committed at research/snapshots/ck-medlineplus-troponin-test.html (fetched as ck-medlineplus-troponin-test.html).",
            "public_text": "quote"
          }
        },
        {
          "evidence_role": "supports",
          "locator": "What is it used for?",
          "applicability_note": "Patient information page, restated in the claim.",
          "snapshot": {
            "id": "cardio:medlineplus-troponin-test-2026-10-15",
            "retrieved_at": "2026-10-15T13:53:26Z",
            "content_hash": "8cedb341bb33f49a54cbd378b43cb92518b65288e0182f3cfd9965371909cc6c",
            "source_effective_date": null,
            "public_archive_url": null,
            "source_state": "current"
          },
          "source": {
            "id": "cardio:medlineplus-troponin-test",
            "source_type": "webpage",
            "title": "Troponin Test (MedlinePlus medical test)",
            "canonical_url": "https://medlineplus.gov/lab-tests/troponin-test/",
            "identifiers": [],
            "publication_date": null,
            "publisher": "U.S. National Library of Medicine (MedlinePlus)",
            "edition": "Page fetched 2026-10-15.",
            "reuse_basis": "MedlinePlus states that works produced by the federal government are not copyrighted, and lists the summaries on health topic pages and medical test information as public domain (the page titled Linking to and Using Content from MedlinePlus, fetched as ck-medlineplus-usingcontent.html, sha256 f70c0b8c67574e30377aab0c22b44038364a37e2e9f54a2ffa67597383b3de34). It names the A.D.A.M. encyclopedia, drug monographs and many images as copyrighted; this atlas uses only the page summary text. Source: MedlinePlus, National Library of Medicine. The raw page is committed at research/snapshots/ck-medlineplus-troponin-test.html (fetched as ck-medlineplus-troponin-test.html).",
            "public_text": "quote"
          }
        },
        {
          "evidence_role": "supports",
          "locator": "What do the results mean?",
          "applicability_note": "Patient information page, restated in the claim.",
          "snapshot": {
            "id": "cardio:medlineplus-troponin-test-2026-10-15",
            "retrieved_at": "2026-10-15T13:53:26Z",
            "content_hash": "8cedb341bb33f49a54cbd378b43cb92518b65288e0182f3cfd9965371909cc6c",
            "source_effective_date": null,
            "public_archive_url": null,
            "source_state": "current"
          },
          "source": {
            "id": "cardio:medlineplus-troponin-test",
            "source_type": "webpage",
            "title": "Troponin Test (MedlinePlus medical test)",
            "canonical_url": "https://medlineplus.gov/lab-tests/troponin-test/",
            "identifiers": [],
            "publication_date": null,
            "publisher": "U.S. National Library of Medicine (MedlinePlus)",
            "edition": "Page fetched 2026-10-15.",
            "reuse_basis": "MedlinePlus states that works produced by the federal government are not copyrighted, and lists the summaries on health topic pages and medical test information as public domain (the page titled Linking to and Using Content from MedlinePlus, fetched as ck-medlineplus-usingcontent.html, sha256 f70c0b8c67574e30377aab0c22b44038364a37e2e9f54a2ffa67597383b3de34). It names the A.D.A.M. encyclopedia, drug monographs and many images as copyrighted; this atlas uses only the page summary text. Source: MedlinePlus, National Library of Medicine. The raw page is committed at research/snapshots/ck-medlineplus-troponin-test.html (fetched as ck-medlineplus-troponin-test.html).",
            "public_text": "quote"
          }
        },
        {
          "evidence_role": "supports",
          "locator": "What do the results mean? (quote 2)",
          "applicability_note": "Patient information page, restated in the claim.",
          "snapshot": {
            "id": "cardio:medlineplus-troponin-test-2026-10-15",
            "retrieved_at": "2026-10-15T13:53:26Z",
            "content_hash": "8cedb341bb33f49a54cbd378b43cb92518b65288e0182f3cfd9965371909cc6c",
            "source_effective_date": null,
            "public_archive_url": null,
            "source_state": "current"
          },
          "source": {
            "id": "cardio:medlineplus-troponin-test",
            "source_type": "webpage",
            "title": "Troponin Test (MedlinePlus medical test)",
            "canonical_url": "https://medlineplus.gov/lab-tests/troponin-test/",
            "identifiers": [],
            "publication_date": null,
            "publisher": "U.S. National Library of Medicine (MedlinePlus)",
            "edition": "Page fetched 2026-10-15.",
            "reuse_basis": "MedlinePlus states that works produced by the federal government are not copyrighted, and lists the summaries on health topic pages and medical test information as public domain (the page titled Linking to and Using Content from MedlinePlus, fetched as ck-medlineplus-usingcontent.html, sha256 f70c0b8c67574e30377aab0c22b44038364a37e2e9f54a2ffa67597383b3de34). It names the A.D.A.M. encyclopedia, drug monographs and many images as copyrighted; this atlas uses only the page summary text. Source: MedlinePlus, National Library of Medicine. The raw page is committed at research/snapshots/ck-medlineplus-troponin-test.html (fetched as ck-medlineplus-troponin-test.html).",
            "public_text": "quote"
          }
        },
        {
          "evidence_role": "supports",
          "locator": "What do the results mean? (quote 3)",
          "applicability_note": "Patient information page, restated in the claim.",
          "snapshot": {
            "id": "cardio:medlineplus-troponin-test-2026-10-15",
            "retrieved_at": "2026-10-15T13:53:26Z",
            "content_hash": "8cedb341bb33f49a54cbd378b43cb92518b65288e0182f3cfd9965371909cc6c",
            "source_effective_date": null,
            "public_archive_url": null,
            "source_state": "current"
          },
          "source": {
            "id": "cardio:medlineplus-troponin-test",
            "source_type": "webpage",
            "title": "Troponin Test (MedlinePlus medical test)",
            "canonical_url": "https://medlineplus.gov/lab-tests/troponin-test/",
            "identifiers": [],
            "publication_date": null,
            "publisher": "U.S. National Library of Medicine (MedlinePlus)",
            "edition": "Page fetched 2026-10-15.",
            "reuse_basis": "MedlinePlus states that works produced by the federal government are not copyrighted, and lists the summaries on health topic pages and medical test information as public domain (the page titled Linking to and Using Content from MedlinePlus, fetched as ck-medlineplus-usingcontent.html, sha256 f70c0b8c67574e30377aab0c22b44038364a37e2e9f54a2ffa67597383b3de34). It names the A.D.A.M. encyclopedia, drug monographs and many images as copyrighted; this atlas uses only the page summary text. Source: MedlinePlus, National Library of Medicine. The raw page is committed at research/snapshots/ck-medlineplus-troponin-test.html (fetched as ck-medlineplus-troponin-test.html).",
            "public_text": "quote"
          }
        }
      ],
      "review": {
        "content_digest": "d31af88fb98e31ecbf57a739c7775c6ffca1d5b74975a084974f8a3c0f28199c",
        "current": [],
        "conflicting": [],
        "stale": [],
        "inactive": []
      },
      "api_path": "api/v1/claims/cardio--claim-troponin-heart-attack-diagnosis.json"
    }
  ],
  "decisions": [],
  "milestones": [],
  "relationships": {
    "outgoing": [
      {
        "predicate": "evaluated_for",
        "label": "Used to help diagnose a heart attack",
        "clinical_claim_not_fact": true,
        "family": "clinical",
        "other_entity_id": "cardio:myocardial-infarction",
        "other_entity_in_atlas": true,
        "claim_id": "cardio:claim-troponin-heart-attack-diagnosis",
        "evidence": null,
        "primary": false,
        "role": null,
        "valid_from": null,
        "valid_to": null
      }
    ],
    "incoming": [
      {
        "predicate": "related_to",
        "label": "Related to",
        "clinical_claim_not_fact": false,
        "family": "navigation",
        "other_entity_id": "core:medlineplus",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": null,
        "primary": false,
        "role": null,
        "valid_from": null,
        "valid_to": null
      },
      {
        "predicate": "measures",
        "label": "Measured by",
        "clinical_claim_not_fact": false,
        "family": "navigation",
        "other_entity_id": "cardio:elecsys-troponin-t-gen5",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": null,
        "primary": false,
        "role": null,
        "valid_from": null,
        "valid_to": null
      }
    ]
  },
  "page_path": "biomarkers/cardiac-troponin/",
  "context_path": "api/v1/context/cardio--cardiac-troponin.md"
}