# TTM2

Study · id `cardio:ttm2` · Cardiovascular Atlas · release `73130c34862e2d06` (public)

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Also called: TTM-2; Targeted Hypothermia Versus Targeted Normothermia After Out-of-hospital Cardiac Arrest

Browse, condition area: Acute care and long-term living  

## In plain language

A randomized trial in 1900 adults who were in a coma after a cardiac arrest outside hospital, of presumed cardiac or unknown cause. One group was cooled to 33 degrees C and then rewarmed in a controlled way; the other was kept at a normal temperature, with the fever treated early. After 6 months, deaths were about the same: 50% with cooling and 48% with normothermia. Heart rhythm problems that affected circulation were more common with cooling (24% against 17%).

## Technical summary

ClinicalTrials.gov NCT02908308: a randomized, parallel-group study, phase not applicable, with Helsingborgs Hospital as lead sponsor (no organization record is kept for it here), status completed, start 2017-11-18, primary completion 2022-06-30 and completion 2022-12-31 (all actual), enrollment 1900 (actual) and locations in 14 countries. The registry lists Luxembourg and the Netherlands under removed countries and they are not counted. It lists masking as triple, while its description says the care team was not blinded; the paper's abstract says open-label with blinded outcome assessment. The primary outcome in the registry is mortality over 180 days; the paper's is death from any cause at 6 months. The record holds no results. The numbers are on the claim.

## Key facts

- Design: Randomized, parallel-group trial. Open-label with blinded assessment of outcomes (abstract); the registry lists masking as triple and its description says the clinical team was not blinded to allocation.
- Phase: Not applicable
- Enrolled: 1900 participants (enrolled count; Targeted Hypothermia Versus Targeted Normothermia After Out-of-hospital Cardiac Arrest, snapshot `cardio:ctgov-nct02908308-2026-10-15`, retrieved 2026-10-15)
- Started: 2017-11-18 (actual) (Targeted Hypothermia Versus Targeted Normothermia After Out-of-hospital Cardiac Arrest, snapshot `cardio:ctgov-nct02908308-2026-10-15`, retrieved 2026-10-15)
- Primary completion: 2022-06-30 (actual) (Targeted Hypothermia Versus Targeted Normothermia After Out-of-hospital Cardiac Arrest, snapshot `cardio:ctgov-nct02908308-2026-10-15`, retrieved 2026-10-15)
- Completion: 2022-12-31 (actual) (Targeted Hypothermia Versus Targeted Normothermia After Out-of-hospital Cardiac Arrest, snapshot `cardio:ctgov-nct02908308-2026-10-15`, retrieved 2026-10-15)
- Countries: United States; Australia; Austria; Belgium; Czechia; Denmark; France; Germany; Italy; New Zealand; Norway; Sweden; Switzerland; United Kingdom (Targeted Hypothermia Versus Targeted Normothermia After Out-of-hospital Cardiac Arrest, snapshot `cardio:ctgov-nct02908308-2026-10-15`, retrieved 2026-10-15)
- Care setting: Not reported
- Registry status: "COMPLETED" (U.S. National Library of Medicine (ClinicalTrials.gov), snapshot `cardio:ctgov-nct02908308-2026-10-15`, retrieved 2026-10-15)

## Connected pages

- Compares cooling to 33 degrees C with targeted normothermia: Temperature control after cardiac arrest (`cardio:temperature-control-after-arrest`)
- Lists out-of-hospital cardiac arrest as its condition: Sudden cardiac arrest (`cardio:sudden-cardiac-arrest`)
- Primary outcome in the paper (death from any cause at 6 months): Death from any cause (`core:outcome-death-any-cause`)

## Provenance

Content hash: 3cbda113eb68f0d13f5ae8b8eebbf0aa11d3bf44c75e7aa923094d6d2e8daa7c
Last substantive edit: 2026-10-15
Evidence last checked: 2026-10-15