# SECURE

Study · id `cardio:secure-trial` · Cardiovascular Atlas · release `5dcd9b263fe17744` (public)

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Also called: Secondary Prevention of Cardiovascular Disease in the Elderly Trial

Browse, organ or system: Heart  
Browse, condition area: Coronary and vascular disease  

## In plain language

A European trial in adults aged 65 or older who had had a heart attack in the previous 6 months and had at least one further risk condition. 2499 patients were randomized to a once-daily polypill combining three heart medicines or to usual care. Over a median of 36 months, the polypill group had fewer major cardiovascular events. Patients in the polypill group reported better adherence, and adverse events were similar between groups.

## Technical summary

Trial (NCT02596126) whose registry lead sponsor is Fundacion Centro Nacional de Investigaciones Cardiovasculares Carlos III (accents removed here), registry phase 3, randomized, parallel, masking none, primary purpose prevention. Sites in seven European countries. The abstract counts 2499 randomized with group denominators of 1237 and 1229; the sources do not explain the difference. The registry holds results posted 2025-05-23, which this record does not extract. Numbers are on the claim. Only the PubMed abstract and the registry record were read.

## Key facts

- Design: Randomized, parallel-group, open-label (masking none in the registry) phase 3 trial of a polypill-based strategy against usual care for secondary prevention after a myocardial infarction. The registry records the primary purpose as prevention.
- Phase: Phase 3
- Enrolled: 2499 participants (enrolled count; Secondary Prevention of Cardiovascular Disease in the Elderly Trial, snapshot `cardio:ctgov-nct02596126-2026-10-15`, retrieved 2026-10-15); 2499 patients (randomized count; Polypill Strategy in Secondary Cardiovascular Prevention, snapshot `cardio:pubmed-36018037-2026-10-15`, retrieved 2026-10-15)
- Started: 2016-07 (Secondary Prevention of Cardiovascular Disease in the Elderly Trial, snapshot `cardio:ctgov-nct02596126-2026-10-15`, retrieved 2026-10-15)
- Primary completion: 2021-10-31 (actual) (Secondary Prevention of Cardiovascular Disease in the Elderly Trial, snapshot `cardio:ctgov-nct02596126-2026-10-15`, retrieved 2026-10-15)
- Completion: 2022-03-31 (actual) (Secondary Prevention of Cardiovascular Disease in the Elderly Trial, snapshot `cardio:ctgov-nct02596126-2026-10-15`, retrieved 2026-10-15)
- Results first posted: 2025-05-23 (actual) (Secondary Prevention of Cardiovascular Disease in the Elderly Trial, snapshot `cardio:ctgov-nct02596126-2026-10-15`, retrieved 2026-10-15)
- Countries: Czechia; France; Germany; Hungary; Italy; Poland; Spain (Secondary Prevention of Cardiovascular Disease in the Elderly Trial, snapshot `cardio:ctgov-nct02596126-2026-10-15`, retrieved 2026-10-15)
- Care setting: Trial sites in seven European countries (Spain, Italy, Germany, France, Hungary, Poland and the Czech Republic), per the registry description. (Secondary Prevention of Cardiovascular Disease in the Elderly Trial, snapshot `cardio:ctgov-nct02596126-2026-10-15`, retrieved 2026-10-15)
- Registry status: "COMPLETED" (U.S. National Library of Medicine (ClinicalTrials.gov), snapshot `cardio:ctgov-nct02596126-2026-10-15`, retrieved 2026-10-15)

## Connected pages

- Tests this care strategy: Cardiovascular polypill (`cardio:polypill`)
- Studies people with this condition: Heart attack (myocardial infarction) (`cardio:myocardial-infarction`)

## Provenance

Content hash: 7b84e3e97d94c50da49a4ea7fd8f32c0a73ee216f214936cb86cc5feeb8c2648
Last substantive edit: 2026-10-15
Evidence last checked: 2026-10-15