# BPLTTC individual-participant meta-analysis, Lancet 2021

Publication · id `cardio:pub-bplttc-lancet-2021` · Cardiovascular Atlas · release `2b2017b84496b985` (public)

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Also called: Blood Pressure Lowering Treatment Trialists' Collaboration 2021

Browse, condition area: Risk and prevention; High blood pressure  

## In plain language

A large analysis that pooled the original patient-level data from 48 randomised trials of blood-pressure-lowering medicines, 344,716 people in all. It asked whether the medicines lower the risk of strokes, heart attacks and heart failure both in people who have already had a stroke, a heart attack or ischaemic heart disease and in people who have not, and at different starting blood pressures. The authors report a similar proportional benefit in both groups.

## Technical summary

The Blood Pressure Lowering Treatment Trialists' Collaboration. Lancet 2021;397(10285):1625-1636. doi:10.1016/S0140-6736(21)00590-0. PMID 33933205. PMC8102467 (open access, CC BY 4.0). PubMed type: Meta-Analysis. A one-stage individual-participant analysis with stratified Cox proportional hazard models; the primary outcome is a major cardiovascular event. This page is a publication record, not a study: it links none of the trials it pools. The one erratum (doi:10.1016/S0140-6736(21)01069-2, PMID 34022983) only updates the collaboration group list. Figure 3 (component outcomes, including stroke alone) is an image that was not read, so no component result is recorded.

## Connected pages

- Published in: The Lancet (`core:lancet`)

## Provenance

Content hash: e54ca9b77e75911195f7a76c6d875cc1949c0c57b721d2b12e6aef4e44c857ab
Last substantive edit: 2026-10-11
Evidence last checked: Not recorded