# Mineralocorticoid receptor antagonists (drug class)

Drug · id `cardio:mineralocorticoid-receptor-antagonists` · Cardiovascular Atlas · release `5dcd9b263fe17744` (public)

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Also called: Aldosterone antagonists

Browse, organ or system: Heart  
Browse, condition area: Heart failure  

## In plain language

A class of medicines that includes the aldosterone antagonists, such as spironolactone. A US government patient page groups aldosterone antagonists with diuretics as medicines that clear excess salt and water from the body, which reduces the volume of blood the heart has to pump. It names them among the medicines commonly used for the reduced type of heart failure, and it lists kidney problems and a high blood potassium level among their possible side effects.

## Technical summary

Class page for the mineralocorticoid receptor antagonists. The source is a US government treatment page, last updated 2022-03-24, which names spironolactone as an example and does not mention blood tests; follow-up blood tests are not stated here. The MeSH heading D000451 is an exact match. One member substance, finerenone, is recorded; no other is.

## Connected pages

- Files under this front: Medicines (`cardio:front-medicines`)
- Has subtype: Finerenone (`cardio:finerenone`)

## Provenance

Content hash: 65a157bae7c1972096505fdede2f2f31bcf83d65beec690f12a74edccc28b041
Last substantive edit: 2026-10-15
Evidence last checked: 2026-10-14