# Heart valve disease

Condition · id `cardio:heart-valve-disease` · Cardiovascular Atlas · release `f6f6f1b6f50379ed` (public)

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Also called: Heart valve diseases; Valvular heart disease

Browse, organ or system: Heart  
Browse, condition area: Valve and congenital heart disease  

## In plain language

Heart valve disease means that at least one of the heart's four valves is not working properly. A valve can leak backward (regurgitation), can be too narrow (stenosis), or can lack an opening (atresia). Some people are born with a valve problem. In others it develops with age or after an infection. A US government patient page says most valve conditions are treatable, with medicine, a repair or a replacement.

## Technical summary

Parent record for the valve conditions in this atlas: aortic stenosis, mitral regurgitation and rheumatic heart disease. A US government patient page names three types of heart valve disease (regurgitation, stenosis and atresia). MeSH D006349 (Heart Valve Diseases) is the matching heading. The atlas has no separate tricuspid regurgitation record, so the records of the tricuspid repair device and its pivotal trial file their link under this one. Replacement and repair covered here: transcatheter aortic valve replacement, surgical aortic valve replacement and transcatheter edge-to-edge repair.

## Connected pages

- Valve replacement through a catheter: Transcatheter aortic valve replacement (TAVR) (`cardio:tavr`)
- Filed under this front: Procedures and surgery (`cardio:front-procedures-and-surgery`)
- Related to: MedlinePlus (`core:medlineplus`)
- Related to: Echocardiography (`core:echocardiography`)
- Related to: Adult congenital heart disease (`cardio:adult-congenital-heart-disease`)
- Has subtype: Aortic stenosis (`cardio:aortic-stenosis`)
- Has subtype: Mitral regurgitation (`cardio:mitral-regurgitation`)
- Related to: Rheumatic heart disease (`cardio:rheumatic-heart-disease`)
- Evaluated for this: TriClip (`cardio:triclip`) [a claim, not a settled fact; see claim `cardio:claim-triluminate-primary` and its context]
- Investigated in: TRILUMINATE Pivotal trial (`cardio:triluminate`)
- Related to: Transcatheter edge-to-edge repair (TEER) (`cardio:transcatheter-edge-to-edge-repair`)

## Provenance

Content hash: 613717fbc3f26418894403b73f1953c497d0471e1ce6f17156616ec4fa8fed95
Last substantive edit: 2026-10-15
Evidence last checked: 2026-10-14