# 2025 ACC/AHA/ACEP/NAEMSP/SCAI guideline for acute coronary syndromes Guideline · id `cardio:guideline-acc-aha-2025-acs` · Cardiovascular Atlas · release `73130c34862e2d06` (public) > General information from published sources, not medical advice, and not reviewed by clinicians. Check the cited source before relying on anything here. The atlas's own text and curation may be reused under Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0, https://creativecommons.org/licenses/by-nc/4.0/): credit the atlas, and do not use it commercially. See the atlas About page. Text quoted from a source stays under that source's own terms, given as the source's reuse\_basis. The atlas's reuse terms do not cover it. The downloads list each quotation with its source in third\_party\_quotations. Browse, condition area: Acute care and long-term living ## In plain language The 2025 US guideline on the management of patients with acute coronary syndromes, issued by the American College of Cardiology and the American Heart Association with three other societies named in its title (ACEP, NAEMSP and SCAI). Its abstract says it brings in evidence published since three earlier guidelines on ST-elevation heart attack, on non-ST-elevation acute coronary syndromes and on primary PCI. Only the abstract could be read, so this page does not give the guideline's recommendations. ## Technical summary Circulation, 2025. PubMed 40014670, DOI 10.1161/CIR.0000000000001309. Three corrections to the Circulation version are listed in PubMed (PMIDs 40163565, 40549849 and 41212941), and their text was not read, so the source state is corrected. Publisher pages return HTTP 403 to scripts, so this is a guideline identity with one descriptive claim. This atlas has no records yet for ACEP, NAEMSP or SCAI. It does not give the guideline's reperfusion targets or timings, because none could be read. ## Claims, with the population each applies to ## Context: Patients with acute coronary syndromes, as covered by the 2025 ACC/AHA/ACEP/NAEMSP/SCAI guideline (abstract) Recipient: Recipient not specified; Population: Patients with acute coronary syndromes. The abstract names earlier guidelines on ST-elevation myocardial infarction and on non-ST-elevation acute coronary syndromes as the base whose evidence it updates, and it states no recommendation for any group.; Care setting: Not stated in the abstract.; Geography: United States (an American College of Cardiology and American Heart Association guideline); the abstract names no other jurisdiction.; Life stage: The abstract states no age limits.; Gestational age: Not reported; Postnatal age: Not reported; Follow-up: Not applicable (guideline). ### The abstract of the 2025 ACC/AHA/ACEP/NAEMSP/SCAI Guideline for the Management of Patients With Acute Coronary Syndromes says it incorporates new evidence since the 2013 ACCF/AHA guideline for ST-elevation myocardial infarction, the corresponding 2014 AHA/ACC guideline for non-ST-elevation acute coronary syndromes and the 2015 ACC/AHA/SCAI focused update on primary percutaneous coronary intervention for ST-elevation myocardial infarction. It says a comprehensive literature search ran from July 2023 to April 2024 across several bibliographic databases, and that many earlier recommendations were updated with new evidence and new ones were created when published data supported them. - Category: Description - Evidence stage: Guidance - Certainty: Certainty not assessed - Applies to: Recipient: Recipient not specified; Population: Patients with acute coronary syndromes. The abstract names earlier guidelines on ST-elevation myocardial infarction and on non-ST-elevation acute coronary syndromes as the base whose evidence it updates, and it states no recommendation for any group.; Care setting: Not stated in the abstract.; Geography: United States (an American College of Cardiology and American Heart Association guideline); the abstract names no other jurisdiction.; Life stage: The abstract states no age limits.; Gestational age: Not reported; Postnatal age: Not reported; Follow-up: Not applicable (guideline). - Limitations: Only the abstract and bibliographic records were read. The full text was not reachable (ahajournals.org returns HTTP 403 to scripts and no other route was tried), so no recommendation, class of recommendation, level of evidence, reperfusion target or timing is recorded here. PubMed links three errata (corrections) to the Circulation version (Circulation 2025 Apr;151(13):e865, PMID 40163565; 2025 Jun 24;151(25):e1098, PMID 40549849; 2025 Nov 11;152(19):e402, PMID 41212941). Their text was not read, so it is not known whether the corrections change anything the abstract says. This claim describes what the abstract says the guideline covers. It is not a recommendation. - Last checked: 2026-10-15 - Source problem: a cited source is corrected. Check the sources before relying on this claim. - Sources: 1. Supports: 2025 ACC/AHA/ACEP/NAEMSP/SCAI Guideline for the Management of Patients With Acute Coronary Syndromes: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines (Publication, edition PubMed record (abstract and bibliographic data) fetched 2026-10-15 through NCBI E-utilities. No PMC copy is listed. Only the abstract was read: publisher pages (ahajournals.org) return HTTP 403 to scripts and were not tried by other means. PubMed links three errata (Circulation 2025 Apr;151(13):e865, PMID 40163565; 2025 Jun 24;151(25):e1098, PMID 40549849; 2025 Nov 11;152(19):e402, PMID 41212941) whose text was not read, so the source state is corrected.) Locator: ArticleTitle, fragment 1 of 2. Retrieved 2026-10-15T13:49:00Z. Source state: Corrected. Snapshot hash: 073d0f62da50e2485673334b533cb83924c205bf026fecff651633bccbee4a44. How it applies: Statement in the cited record. 2. Supports: 2025 ACC/AHA/ACEP/NAEMSP/SCAI Guideline for the Management of Patients With Acute Coronary Syndromes: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines (Publication, edition PubMed record (abstract and bibliographic data) fetched 2026-10-15 through NCBI E-utilities. No PMC copy is listed. Only the abstract was read: publisher pages (ahajournals.org) return HTTP 403 to scripts and were not tried by other means. PubMed links three errata (Circulation 2025 Apr;151(13):e865, PMID 40163565; 2025 Jun 24;151(25):e1098, PMID 40549849; 2025 Nov 11;152(19):e402, PMID 41212941) whose text was not read, so the source state is corrected.) Locator: ArticleTitle, fragment 2 of 2. Retrieved 2026-10-15T13:49:00Z. Source state: Corrected. Snapshot hash: 073d0f62da50e2485673334b533cb83924c205bf026fecff651633bccbee4a44. How it applies: Statement in the cited record. 3. Supports: 2025 ACC/AHA/ACEP/NAEMSP/SCAI Guideline for the Management of Patients With Acute Coronary Syndromes: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines (Publication, edition PubMed record (abstract and bibliographic data) fetched 2026-10-15 through NCBI E-utilities. No PMC copy is listed. Only the abstract was read: publisher pages (ahajournals.org) return HTTP 403 to scripts and were not tried by other means. PubMed links three errata (Circulation 2025 Apr;151(13):e865, PMID 40163565; 2025 Jun 24;151(25):e1098, PMID 40549849; 2025 Nov 11;152(19):e402, PMID 41212941) whose text was not read, so the source state is corrected.) Locator: Abstract, AIM, sentence 1, fragment 1 of 3. Retrieved 2026-10-15T13:49:00Z. Source state: Corrected. Snapshot hash: 073d0f62da50e2485673334b533cb83924c205bf026fecff651633bccbee4a44. How it applies: Aim of the guideline, stated in the abstract. 4. Supports: 2025 ACC/AHA/ACEP/NAEMSP/SCAI Guideline for the Management of Patients With Acute Coronary Syndromes: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines (Publication, edition PubMed record (abstract and bibliographic data) fetched 2026-10-15 through NCBI E-utilities. No PMC copy is listed. Only the abstract was read: publisher pages (ahajournals.org) return HTTP 403 to scripts and were not tried by other means. PubMed links three errata (Circulation 2025 Apr;151(13):e865, PMID 40163565; 2025 Jun 24;151(25):e1098, PMID 40549849; 2025 Nov 11;152(19):e402, PMID 41212941) whose text was not read, so the source state is corrected.) Locator: Abstract, AIM, sentence 1, fragment 2 of 3. Retrieved 2026-10-15T13:49:00Z. Source state: Corrected. Snapshot hash: 073d0f62da50e2485673334b533cb83924c205bf026fecff651633bccbee4a44. How it applies: Aim of the guideline, stated in the abstract. 5. Supports: 2025 ACC/AHA/ACEP/NAEMSP/SCAI Guideline for the Management of Patients With Acute Coronary Syndromes: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines (Publication, edition PubMed record (abstract and bibliographic data) fetched 2026-10-15 through NCBI E-utilities. No PMC copy is listed. Only the abstract was read: publisher pages (ahajournals.org) return HTTP 403 to scripts and were not tried by other means. PubMed links three errata (Circulation 2025 Apr;151(13):e865, PMID 40163565; 2025 Jun 24;151(25):e1098, PMID 40549849; 2025 Nov 11;152(19):e402, PMID 41212941) whose text was not read, so the source state is corrected.) Locator: Abstract, AIM, sentence 1, fragment 3 of 3. Retrieved 2026-10-15T13:49:00Z. Source state: Corrected. Snapshot hash: 073d0f62da50e2485673334b533cb83924c205bf026fecff651633bccbee4a44. How it applies: Aim of the guideline, stated in the abstract. 6. Supports: 2025 ACC/AHA/ACEP/NAEMSP/SCAI Guideline for the Management of Patients With Acute Coronary Syndromes: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines (Publication, edition PubMed record (abstract and bibliographic data) fetched 2026-10-15 through NCBI E-utilities. No PMC copy is listed. Only the abstract was read: publisher pages (ahajournals.org) return HTTP 403 to scripts and were not tried by other means. PubMed links three errata (Circulation 2025 Apr;151(13):e865, PMID 40163565; 2025 Jun 24;151(25):e1098, PMID 40549849; 2025 Nov 11;152(19):e402, PMID 41212941) whose text was not read, so the source state is corrected.) Locator: Abstract, AIM, sentence 2, fragment 1 of 2. Retrieved 2026-10-15T13:49:00Z. Source state: Corrected. Snapshot hash: 073d0f62da50e2485673334b533cb83924c205bf026fecff651633bccbee4a44. How it applies: Aim of the guideline, stated in the abstract. 7. Supports: 2025 ACC/AHA/ACEP/NAEMSP/SCAI Guideline for the Management of Patients With Acute Coronary Syndromes: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines (Publication, edition PubMed record (abstract and bibliographic data) fetched 2026-10-15 through NCBI E-utilities. No PMC copy is listed. Only the abstract was read: publisher pages (ahajournals.org) return HTTP 403 to scripts and were not tried by other means. PubMed links three errata (Circulation 2025 Apr;151(13):e865, PMID 40163565; 2025 Jun 24;151(25):e1098, PMID 40549849; 2025 Nov 11;152(19):e402, PMID 41212941) whose text was not read, so the source state is corrected.) Locator: Abstract, AIM, sentence 2, fragment 2 of 2. Retrieved 2026-10-15T13:49:00Z. Source state: Corrected. Snapshot hash: 073d0f62da50e2485673334b533cb83924c205bf026fecff651633bccbee4a44. How it applies: Aim of the guideline, stated in the abstract. 8. Supports: 2025 ACC/AHA/ACEP/NAEMSP/SCAI Guideline for the Management of Patients With Acute Coronary Syndromes: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines (Publication, edition PubMed record (abstract and bibliographic data) fetched 2026-10-15 through NCBI E-utilities. No PMC copy is listed. Only the abstract was read: publisher pages (ahajournals.org) return HTTP 403 to scripts and were not tried by other means. PubMed links three errata (Circulation 2025 Apr;151(13):e865, PMID 40163565; 2025 Jun 24;151(25):e1098, PMID 40549849; 2025 Nov 11;152(19):e402, PMID 41212941) whose text was not read, so the source state is corrected.) Locator: Abstract, METHODS, sentence 1. Retrieved 2026-10-15T13:49:00Z. Source state: Corrected. Snapshot hash: 073d0f62da50e2485673334b533cb83924c205bf026fecff651633bccbee4a44. How it applies: Design, population or outcome definition in the abstract. 9. Supports: 2025 ACC/AHA/ACEP/NAEMSP/SCAI Guideline for the Management of Patients With Acute Coronary Syndromes: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines (Publication, edition PubMed record (abstract and bibliographic data) fetched 2026-10-15 through NCBI E-utilities. No PMC copy is listed. Only the abstract was read: publisher pages (ahajournals.org) return HTTP 403 to scripts and were not tried by other means. PubMed links three errata (Circulation 2025 Apr;151(13):e865, PMID 40163565; 2025 Jun 24;151(25):e1098, PMID 40549849; 2025 Nov 11;152(19):e402, PMID 41212941) whose text was not read, so the source state is corrected.) Locator: Abstract, METHODS, sentence 2, fragment 1 of 2. Retrieved 2026-10-15T13:49:00Z. Source state: Corrected. Snapshot hash: 073d0f62da50e2485673334b533cb83924c205bf026fecff651633bccbee4a44. How it applies: Design, population or outcome definition in the abstract. 10. Supports: 2025 ACC/AHA/ACEP/NAEMSP/SCAI Guideline for the Management of Patients With Acute Coronary Syndromes: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines (Publication, edition PubMed record (abstract and bibliographic data) fetched 2026-10-15 through NCBI E-utilities. No PMC copy is listed. Only the abstract was read: publisher pages (ahajournals.org) return HTTP 403 to scripts and were not tried by other means. PubMed links three errata (Circulation 2025 Apr;151(13):e865, PMID 40163565; 2025 Jun 24;151(25):e1098, PMID 40549849; 2025 Nov 11;152(19):e402, PMID 41212941) whose text was not read, so the source state is corrected.) Locator: Abstract, METHODS, sentence 2, fragment 2 of 2. Retrieved 2026-10-15T13:49:00Z. Source state: Corrected. Snapshot hash: 073d0f62da50e2485673334b533cb83924c205bf026fecff651633bccbee4a44. How it applies: Design, population or outcome definition in the abstract. 11. Supports: 2025 ACC/AHA/ACEP/NAEMSP/SCAI Guideline for the Management of Patients With Acute Coronary Syndromes: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines (Publication, edition PubMed record (abstract and bibliographic data) fetched 2026-10-15 through NCBI E-utilities. No PMC copy is listed. Only the abstract was read: publisher pages (ahajournals.org) return HTTP 403 to scripts and were not tried by other means. PubMed links three errata (Circulation 2025 Apr;151(13):e865, PMID 40163565; 2025 Jun 24;151(25):e1098, PMID 40549849; 2025 Nov 11;152(19):e402, PMID 41212941) whose text was not read, so the source state is corrected.) Locator: Abstract, STRUCTURE, sentence 1. Retrieved 2026-10-15T13:49:00Z. Source state: Corrected. Snapshot hash: 073d0f62da50e2485673334b533cb83924c205bf026fecff651633bccbee4a44. How it applies: How the guideline is organised, stated in the abstract. ## Connected pages - Co-issuer, with the American Heart Association and three other societies: American College of Cardiology (`core:acc`) - Co-issuer, with the American College of Cardiology and three other societies: American Heart Association (`core:aha`) ## Provenance Content hash: e0846711625331641fb135e8b06abe7877488666fe144f18e90271f4a80c0198 Last substantive edit: 2026-10-15 Evidence last checked: 2026-10-15